Emerging treatments
Nicotinamide
Nicotinamide (vitamin B3 or niacinamide) is a substrate and inhibitor of poly-ADP-ribose polymerase, and a precursor of nicotinamide adenine dinucleotide, both of which are involved in DNA repair. There is evidence to suggest that oral nicotinamide reduces the rates of new AKs in high-risk patients.[125]
Low-dose fluorouracil in salicylic acid
Topical fluorouracil (0.5%)/salicylic acid (10%) demonstrated superior sustained clinical efficacy compared with topical diclofenac (3%) in a randomised controlled multicentre trial.[93] Local adverse effects (inflammation and burning) were more common with topical fluorouracil/salicylic acid. Marketed in Europe for the topical treatment of slightly palpable and/or moderately thick hyperkeratotic AK (grade I/II) in immunocompetent adult patients. The combination has not been approved by the US Food and Drug Administration.
Use of this content is subject to our disclaimer