Severe combined immunodeficiency

Genetic counselling is indicated in families of infants with SCID.[21]Heimall J, Buckley RH, Puck J, et al. Recommendations for screening and management of late effects in patients with severe combined immunodeficiency after allogenic hematopoietic cell transplantation: a consensus statement from the second pediatric blood and marrow transplant consortium international conference on late effects after pediatric HCT. Biol Blood Marrow Transplant. 2017 Aug;23(8):1229-40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015789 http://www.ncbi.nlm.nih.gov/pubmed/28479164?tool=bestpractice.com Increased vigilance is warranted for infants with a family history of SCID, or a family history of early infant death (<2 years of age) due to infection, or failure to thrive.