Parasomnias in adults

Melatonergic agents

A case report suggests that the melatonergic agents agomelatine and extended-release melatonin can aid in relieving sleep-related eating disorder.[92]Zapp AA, Fischer EC, Deuschle M. The effect of agomelatine and melatonin on sleep-related eating: a case report. Journal of Medical Case Reports. 2017;11:275. http://www.ncbi.nlm.nih.gov/pubmed/28954634?tool=bestpractice.com ​ Extended-release melatonin has been studied for the treatment of rapid eye movement sleep behaviour disorder (RBD). While findings are conflicting, a 'chronobiotic' protocol of low-dose extended-release melatonin given at the same time nightly improved RBD symptoms even several months after treatment discontinuation.[93]Kunz D, Stotz S, Bes F. Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic. J Pineal Res. 2021 Sep;71(2):e12759. https://onlinelibrary.wiley.com/doi/10.1111/jpi.12759 http://www.ncbi.nlm.nih.gov/pubmed/34309908?tool=bestpractice.com