Summary
Definition
History and exam
Key diagnostic factors
- coronary artery disease
- presence of other risk factors
- tachycardia
- hypotension
Other diagnostic factors
- weak pulse
- syncope
- presyncope
- airway compromise
- impaired consciousness
- light-headedness
- dizziness
- diminished responsiveness
- chest discomfort
- dyspnoea
- asymptomatic
Risk factors
- coronary artery disease
- acute myocardial infarction
- left ventricular systolic dysfunction
- hypertrophic cardiomyopathy
- long QT syndrome
- short QT syndrome
- Brugada syndrome
- sleep-disordered breathing (SDB)
- family history of sudden death
- mental or physical stress
- ventricular pre-excitation
- arrhythmogenic right ventricular cardiomyopathy
- electrolyte imbalance
- drug toxicity
- Chagas disease, and other cardiomyopathies
Diagnostic investigations
Investigations to consider
- cardiac catheterisation
- cardiac MRI
- electrophysiological (EP) study
- genetic testing
Treatment algorithm
Contributors
Authors
Sei Iwai, MD, FACC, FHRS
Professor of Clinical Medicine
New York Medical College
Section Chief, Cardiac Electrophysiology
Westchester Medical Center Health Network
Valhalla
NY
Disclosures
SI is an author of some references cited in this topic.
Acknowledgements
Professor Sei Iwai would like to gratefully acknowledge Dr Kenneth Stein and Dr Richard Keating, previous contributors to this topic.
Disclosures
KS declares he is an employee of and shareholder in Boston Scientific, a manufacturer of implantable cardioverter defibrillators and ablation catheters. RK declares that he has no competing interests.
Peer reviewers
Suneet Mittal, MD
Director
Electrophysiology Laboratory
The St. Luke's-Roosevelt Hospital Center
New York
NY
Disclosures
SM declares that he has no competing interests.
Kenneth A. Ellenbogen, MD
Kontos Professor of Cardiology
Medical College of Virginia
Richmond
VA
Disclosures
KAE declares that he has no competing interests.
Kim Rajappan, MA, MD, MRCP
Consultant Cardiologist and Electrophysiologist
Cardiac Department
John Radcliffe Hospital
Oxford
UK
Disclosures
KR declares that she has no competing interests.
References
Key articles
Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022 Oct 21;43(40):3997-4126.Full text Abstract
Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS Guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2018 Oct 2;72(14):e91-220. Abstract
Panchal AR, Bartos JA, Cabañas JG, et al; Adult Basic and Advanced Life Support Writing Group. Part 3: adult basic and advanced life support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2020 Oct 20;142(16_suppl_2):S366-468.Full text Abstract
Cronin EM, Bogun FM, Maury P, et al. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. J Arrhythm. 2019 May 10;35(3):323-484.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available here.
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