References
Key articles
Taylor PN, Medici MM, Hubalewska-Dydejczyk A, et al. Hypothyroidism. Lancet. 2024 Oct 5;404(10460):1347-64. Abstract
Alexander EK, Pearce EN, Brent GA, et al. 2017 guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017 Mar;27(3):315-89.Full text Abstract
American Association of Clinical Endocrinologists; American Thyroid Association. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012 Nov-Dec;18(6):988-1028.Full text Abstract
Jonklaas J, Bianco AC, Bauer AJ, et al. Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement. Thyroid. 2014 Dec;24(12):1670-751.Full text Abstract
Reference articles
1. Chaker L, Razvi S, Bensenor IM, et al. Hypothyroidism. Nat Rev Dis Primers. 2022 May 19;8(1):30. Abstract
2. Taylor PN, Medici MM, Hubalewska-Dydejczyk A, et al. Hypothyroidism. Lancet. 2024 Oct 5;404(10460):1347-64. Abstract
3. Cooper DS, Biondi B, Cappola AR. Subclinical hypothyroidism: a review. JAMA. 2019 Jul 9;322(2):153-60. Abstract
4. Elkattawy S, Dhanoa P, Kotys J, et al. Myxedema coma: case report and literature review. Cureus. 2021 May 27;13(5):e15277.Full text Abstract
5. Taylor PN, Albrecht D, Scholz A, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018 May;14(5):301-16. Abstract
6. Vanderpump MP, Tunbridge WM, French JM, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey. Clin Endocrinol. 1995 Jul;43(1):55-68. Abstract
7. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4) and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002 Feb;87(2):489-99.Full text Abstract
8. Wyne KL, Nair L, Schneiderman CP, et al. Hypothyroidism prevalence in the United States: a retrospective study combining National Health and Nutrition Examination Survey and Claims Data, 2009-2019. J Endocr Soc. 2022 Nov 17;7(1):bvac172.Full text Abstract
9. Canaris GJ, Manowitz NR, Mayor G, et al. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000 Feb 28;160(4):526-34. Abstract
10. Han X, Ding S, Lu J, et al. Global, regional, and national burdens of common micronutrient deficiencies from 1990 to 2019: a secondary trend analysis based on the Global Burden of Disease 2019 study. EClinicalMedicine. 2022 Feb;44:101299.Full text Abstract
11. Dold S, Zimmermann MB, Jukic T, et al. Universal salt iodization provides sufficient dietary iodine to achieve adequate iodine nutrition during the first 1000 days: a cross-sectional multicenter study. J Nutr. 2018 Apr 1;148(4):587-98.Full text Abstract
12. Zimmermann MB, Andersson M. Global endocrinology: global perspectives in endocrinology: coverage of iodized salt programs and iodine status in 2020. Eur J Endocrinol. 2021 Jun 10;185(1):R13-21.Full text Abstract
13. Lazarus JH. The importance of iodine in public health. Environ Geochem Health. 2015 Aug;37(4):605-18.Full text Abstract
14. Caldwell KL, Pan Y, Mortensen ME, et al. Iodine status in pregnant women in the National Children's Study and in US women (15-44 years), National Health and Nutrition Examination Survey 2005-2010. Thyroid. 2013 Aug;23(8):927-37.Full text Abstract
15. Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med. 2003 Jun 26;348(26):2646-55. Abstract
16. Hu X, Chen Y, Shen Y, et al. Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: a systematic review and meta-analysis. Front Public Health. 2022 Oct 13;10:1020709.Full text Abstract
17. Ragusa F, Fallahi P, Elia G, et al. Hashimotos' thyroiditis: epidemiology, pathogenesis, clinic and therapy. Best Pract Res Clin Endocrinol Metab. 2019 Dec;33(6):101367. Abstract
18. Solmunde E, Falstie-Jensen AM, Lorenzen EL, et al. Breast cancer, breast cancer-directed radiation therapy and risk of hypothyroidism: a systematic review and meta-analysis. Breast. 2023 Apr;68:216-24.Full text Abstract
19. Rizzo LFL, Mana DL, Serra HA. Drug-induced hypothyroidism. Medicina (B Aires). 2017;77(5):394-404.Full text Abstract
20. Gabora K, Piciu A, Bădulescu IC, et al. Current evidence on thyroid related adverse events in patients treated with protein tyrosine kinase inhibitors. Drug Metab Rev. 2019 Nov;51(4):562-569.Full text Abstract
21. Micali C, Russotto Y, Celesia BM, et al. Thyroid diseases and thyroid asymptomatic dysfunction in people living with HIV. Infect Dis Rep. 2022 Sep 1;14(5):655-67.Full text Abstract
22. Bianco AC, Dumitrescu A, Gereben B, et al. Paradigms of dynamic control of thyroid hormone signaling. Endocr Rev. 2019 Aug 1;40(4):1000-47.Full text Abstract
23. Oetting A, Yen PM. New insights into thyroid hormone action. Best Pract Res Clin Endocrinol Metab. 2007 Jun;21(2):193-208. Abstract
24. Sorrenti S, Baldini E, Pironi D, et al. Iodine: its role in thyroid hormone biosynthesis and beyond. Nutrients. 2021 Dec 14;13(12):4469.Full text Abstract
25. Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015 Apr;3(4):286-95. Abstract
26. Lisco G, De Tullio A, Triggiani D, et al. Iodine Deficiency and Iodine Prophylaxis: An Overview and Update. Nutrients. 2023 Feb 16;15(4):.Full text Abstract
27. Rayman MP. Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease. Proc Nutr Soc. 2019 Feb;78(1):34-44.Full text Abstract
28. Leung AM, Braverman LE. Consequences of excess iodine. Nat Rev Endocrinol. 2014 Mar;10(3):136-42.Full text Abstract
29. Kahaly GJ, Frommer L. Polyglandular autoimmune syndromes. J Endocrinol Invest. 2018 Jan;41(1):91-8. Abstract
30. Trohman RG, Sharma PS, McAninch EA, et al. Amiodarone and thyroid physiology, pathophysiology, diagnosis and management. Trends Cardiovasc Med. 2019 Jul;29(5):285-295.Full text Abstract
31. Apostolou K, Paunovic I, Frountzas M, et al. Posthemithyroidectomy hypothyroidism: updated meta-analysis of risk factors and rates of remission. J Surg Res. 2024 Jan;293:102-20. Abstract
32. Shearn-Nance G, Politano S, Cabrera CI, et al. Development of hypothyroidism following hemithyroidectomy: a population-based study. Am J Otolaryngol. 2024 May-Jun;45(3):104239. Abstract
33. Cooper D, Kaur R, Ayeni FE, et al. Hypothyroidism after hemithyroidectomy: a systematic review and meta-analysis. Thyroid Res. 2024 Jul 8;17(1):18.Full text Abstract
34. Keely EJ. Postpartum thyroiditis: an autoimmune thyroid disorder which predicts future thyroid health. Obstet Med. 2011 Mar;4(1):7-11.Full text Abstract
35. Kyritsi EM, Kanaka-Gantenbein C. Autoimmune Thyroid Disease in Specific Genetic Syndromes in Childhood and Adolescence. Front Endocrinol (Lausanne). 2020 Aug 19;11:543.Full text Abstract
36. Huber A, Menconi F, Corathers S, et al. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev. 2008 Oct;29(6):697-725.Full text Abstract
37. Alexander L, Cheng-Ting T, Åke L, et al. Type 1 diabetes, celiac disease, and autoimmune thyroiditis autoantibodies in population-based type 2 diabetes patients. J Clin Transl Endocrinol. 2024 Sep;37:100367.Full text Abstract
38. Hwang GB, Yoon JS, Park KJ, et al. Prevalence of autoimmune thyroiditis in patients with type 1 diabetes: a long-term follow-up study. Ann Pediatr Endocrinol Metab. 2018 Mar;23(1):33-7.Full text Abstract
39. Piątkowska E, Szalecki M. Autoimmune thyroiditis in children and adolescents with type 1 diabetes. Pediatr Endocrinol Diabetes Metab. 2011;17(4):173-7. Abstract
40. Rooney MK, Andring LM, Corrigan KL, et al. Hypothyroidism following radiotherapy for head and neck cancer: a systematic review of the literature and opportunities to improve the therapeutic ratio. Cancers (Basel). 2023 Aug 29;15(17):4321.Full text Abstract
41. Sirikul W, Sapbamrer R. Exposure to pesticides and the risk of hypothyroidism: a systematic review and meta-analysis. BMC Public Health. 2023 Sep 26;23(1):1867.Full text Abstract
42. Zhong B, Wang Y, Zhang G, et al. Environmental iodine content, female sex and age are associated with new-onset amiodarone-induced hypothyroidism: a systematic review and meta-analysis of adverse reactions of amiodarone on the thyroid. Cardiology. 2016;134(3):366-71. Abstract
43. Mohammadi K, Shafie D, Vakhshoori M, et al. Prevalence of amiodarone-induced hypothyroidism; a systematic review and meta-analysis. Trends Cardiovasc Med. 2023 May;33(4):252-62. Abstract
44. Rahimi-Bashar F, Vahedian-Azimi A, Dalvand S, et al. Prevalence of amiodarone induced hypothyroidism and hyperthyroidism in patients with heart diseases: a systematic review and meta-analysis. Curr Med Chem. 2023;30(23):2690-9. Abstract
45. Banyi N, Kwon JJY, Turkdogan S, et al. Incidence and complications of hypothyroidism postlaryngectomy: a systematic review and meta-analysis. Head Neck. 2024 Feb;46(2):249-61. Abstract
46. Tola HH, Holakouie-Naieni K, Lejisa T, et al. Is hypothyroidism rare in multidrug resistance tuberculosis patients on treatment? a systematic review and meta-analysis. PLoS One. 2019;14(6):e0218487.Full text Abstract
47. Quiroz-Aldave JE, Durand-Vásquez MDC, Gamarra-Osorio ER, et al. Drug-induced hypothyroidism in tuberculosis. Expert Rev Endocrinol Metab. 2024 May;19(3):199-206. Abstract
48. Harding KB, Peña-Rosas JP, Webster AC, et al. Iodine supplementation for women during the preconception, pregnancy and postpartum period. Cochrane Database Syst Rev. 2017 Mar 5;3(3):CD011761.Full text Abstract
49. World Health Organization. e-Library of evidence for nutrition actions (eLENA): iodine supplementation in pregnant and lactating women. Aug 2023 [internet publication].Full text
50. Siskind SM, Lee SY, Pearce EN. Investigating hypothyroidism. BMJ. 2021 Apr 27;373:n993.Full text Abstract
51. British Columbia Ministry of Health. Thyroid function testing in the diagnosis and monitoring of thyroid function disorder. Dec 2022 [internet publication].Full text
52. Carlé A, Pedersen IB, Knudsen N, et al. Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case-control study. Eur J Endocrinol. 2014 Nov;171(5):593-602. Abstract
53. Canaris GJ, Steiner JF, Ridgway EC. Do traditional symptoms of hypothyroidism correlate with biochemical disease? J Gen Intern Med. 1997 Sep;12(9):544-50.Full text Abstract
54. Ferreira-Hermosillo A, Toledo JO, Cordoba K. Evaluation of the risk of hypothyroidism and its clinical manifestations using the Zulewski scale. Front Endocrinol (Lausanne). 2024 Aug 16;15:1416663.Full text Abstract
55. National Institute for Health and Care Excellence. Thyroid disease: assessment and management. Oct 2023 [internet publication].Full text
56. Alexander EK, Pearce EN, Brent GA, et al. 2017 guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017 Mar;27(3):315-89.Full text Abstract
57. Wopereis DM, Du Puy RS, van Heemst D, et al. The relation between thyroid function and anemia: a pooled analysis of individual participant data. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3658-67.Full text Abstract
58. Hage MP, Azar ST. The link between thyroid function and depression. J Thyroid Res. 2012;2012:590648.Full text Abstract
59. Urmi SJ, Begum SR, Fariduddin M, et al. Hypothyroidism and its effect on menstrual pattern and fertility. Mymensingh Med J. 2015 Oct;24(4):765-9. Abstract
60. Berta E, Lengyel I, Halmi S, et al. Hypertension in thyroid disorders. Front Endocrinol (Lausanne). 2019 Jul 17;10:482.Full text Abstract
61. Cappola AR, Desai AS, Medici M, et al. Thyroid and cardiovascular disease: research agenda for enhancing knowledge, prevention, and treatment. Circulation. 2019 Jun 18;139(25):2892-909.Full text Abstract
62. American Association of Clinical Endocrinologists; American Thyroid Association. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012 Nov-Dec;18(6):988-1028.Full text Abstract
63. Persani L, Cangiano B, Bonomi M. The diagnosis and management of central hypothyroidism in 2018. Endocr Connect. 2019 Feb;8(2):R44-R54.Full text Abstract
64. Samuels MH. Psychiatric and cognitive manifestations of hypothyroidism. Curr Opin Endocrinol Diabetes Obes. 2014 Oct;21(5):377-83.Full text Abstract
65. Mintziori G, Veneti S, Poppe K, et al. EMAS position statement: thyroid disease and menopause. Maturitas. 2024 Jul;185:107991.Full text Abstract
66. LeFevre ML, U.S. Preventive Services Task Force. Screening for thyroid dysfunction: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2015 May 5;162(9):641-50.Full text Abstract
67. Rastogi MV, LaFranchi SH. Congenital hypothyroidism. Orphanet J Rare Dis. 2010 Jun 10;5:17.Full text Abstract
68. Kopel J. A global perspective on newborn congenital hypothyroidism screening. Proc (Bayl Univ Med Cent). 2020 Jan;33(1):137-9.Full text Abstract
69. Rose SR, Wassner AJ, Wintergerst KA, et al. Congenital hypothyroidism: screening and management. Pediatrics. 2023 Jan 1;151(1):e2022060419.Full text Abstract
70. Rugge JB, Bougatsos C, Chou R. Screening and treatment of thyroid dysfunction: an evidence review for the US Preventive Services Task Force. Ann Intern Med. 2015 Jan 6;162(1):35-45.Full text Abstract
71. Vissenberg R, van den Boogaard E, van Wely M, et al. Treatment of thyroid disorders before conception and in early pregnancy: a systematic review. Hum Reprod Update. 2012 Jul;18(4):360-7. Abstract
72. Spencer L, Bubner T, Bain E, et al. Screening and subsequent management for thyroid dysfunction pre-pregnancy and during pregnancy for improving maternal and infant health. Cochrane Database Syst Rev. 2015 Sep 21;2015(9):CD011263.Full text Abstract
73. Reid SM, Middleton P, Cossich MC, et al. Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy. Cochrane Database Syst Rev. 2013 May 31;(5):CD007752.Full text Abstract
74. Negro R, Schwartz A, Gismondi R, et al. Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy. J Clin Endocrinol Metab. 2010 Apr;95(4):1699-707. Abstract
75. American College of Obstetricians and Gynecologists. Thyroid disease in pregnancy: ACOG practice bulletin, number 223. Obstet Gynecol. 2020 Jun;135(6):e261-74. Abstract
76. Jonklaas J, Bianco AC, Bauer AJ, et al. Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement. Thyroid. 2014 Dec;24(12):1670-751.Full text Abstract
77. Villar HC, Saconato H, Valente O, et al. Thyroid hormone replacement for subclinical hypothyroidism. Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD003419.Full text Abstract
78. Pearce SH, Brabant G, Duntas LH, et al. 2013 ETA guideline: management of subclinical hypothyroidism. Eur Thyroid J. 2013 Dec;2(4):215-28.Full text Abstract
79. Ku EJ, Yoo WS, Chung HK. Management of subclinical hypothyroidism: a focus on proven health effects in the 2023 Korean Thyroid Association guidelines. Endocrinol Metab (Seoul). 2023 Aug;38(4):381-91.Full text Abstract
80. Feller M, Snel M, Moutzouri E, et al. Association of thyroid hormone therapy with quality of life and thyroid-related symptoms in patients with subclinical hypothyroidism: a systematic review and meta-analysis. JAMA. 2018 Oct 2;320(13):1349-59.Full text Abstract
81. Bekkering GE, Agoritsas T, Lytvyn L, et al. Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline. BMJ. 2019 May 14;365:l2006. Abstract
82. Rodondi N, den Elzen WP, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010 Sep 22;304(12):1365-74. Abstract
83. Stott DJ, Rodondi N, Kearney PM, et al. Thyroid hormone therapy for older adults with subclinical hypothyroidism. N Engl J Med. 2017 Jun 29;376(26):2534-44.Full text Abstract
84. Dhillon-Smith RK, Boelaert K, Jeve YB, et al. Subclinical hypothyroidism and antithyroid autoantibodies in women with subfertility or recurrent pregnancy loss: scientific impact paper no. 70 June 2022: scientific impact paper no. 70 June 2022. BJOG. 2022 Nov;129(12):e75-88.Full text Abstract
85. Triggiani V, Cittadini A, Lisco G. Effect of levothyroxine replacement therapy in patients with subclinical hypothyroidism and chronic heart failure: a systematic review. Front Endocrinol (Lausanne). 2022 Nov 15;13:1013641.Full text Abstract
86. Jiao XF, Zhang M, Chen J, et al. The impact of levothyroxine therapy on the pregnancy, neonatal and childhood outcomes of subclinical hypothyroidism during pregnancy: an updated systematic review, meta-analysis and trial sequential analysis. Front Endocrinol (Lausanne). 2022 Aug 5;13:964084.Full text Abstract
87. Akhtar MA, Agrawal R, Brown J, et al. Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism. Cochrane Database Syst Rev. 2019 Jun 25;6(6):CD011009.Full text Abstract
88. Biondi B, Cappola AR. Subclinical hypothyroidism in older individuals. Lancet Diabetes Endocrinol. 2022 Feb;10(2):129-41. Abstract
89. Roos A, Linn-Rasker SP, van Domburg RT, et al. The starting dose of levothyroxine in primary hypothyroidism treatment: a prospective, randomized, double-blind trial. Arch Intern Med. 2005 Aug 8-22;165(15):1714-20.Full text Abstract
90. Lee SY, Pearce EN. Assessment and treatment of thyroid disorders in pregnancy and the postpartum period. Nat Rev Endocrinol. 2022 Mar;18(3):158-71.Full text Abstract
91. Okosieme O, Gilbert J, Abraham P, et al. Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee. Clin Endocrinol (Oxf). 2016 Jun;84(6):799-808.Full text Abstract
92. Thayakaran R, Adderley NJ, Sainsbury C, et al. Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study. BMJ. 2019 Sep 3;366:l4892.Full text Abstract
93. Maraka S, Mwangi R, McCoy RG, et al. Thyroid hormone treatment among pregnant women with subclinical hypothyroidism: US national assessment. BMJ. 2017;356:i6865.Full text Abstract
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