Arginine vasopressin deficiency or resistance (Diabetes insipidus)

Overview 
Theory 
Diagnosis 
Management 
Follow up 
Resources 

There is no screening for arginine vasopressin deficiency (AVP-D) or arginine vasopressin resistance (AVP-R) in the general population. Evidence of familial AVP-D or AVP-R should prompt consideration of focused genetic testing. AVP-neurophysin gene studies can be used for predictive screening in families with autosomal dominant familial AVP-D.[39] In patients with visual failure with optic atrophy and sensorineural deafness, consider WFS1 gene studies for Wolfram syndrome (also called DIDMOAD [diabetes insipidus, diabetes mellitus, optic atrophy, and deafness] syndrome).[41]

Following pituitary or para-pituitary surgery, assessment of pituitary function with the water deprivation test will establish the presence or absence of AVP-D.[3]

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Arginine vasopressin deficiency or resistance (Diabetes insipidus)

Screening