References
Key articles
Shen WK, Sheldon RS, Benditt DG, et al. 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society. Circulation. 2017 Aug 1;136(5):e60-122.Full text Abstract
Brignole M, Moya A, de Lange FJ, et al. 2018 ESC guidelines for the diagnosis and management of syncope. Eur Heart J. 2018 Jun 1;39(21):1883-948.Full text Abstract
American College of Radiology. ACR appropriateness criteria: syncope. 2020 [internet publication].Full text
Reference articles
1. Sun BC. Quality-of-life, health service use, and costs associated with syncope. Prog Cardiovasc Dis. 2013 Jan-Feb;55(4):370-75.Full text Abstract
2. Centers for Disease Control and Prevention. National hospital ambulatory medical care survey: 2019 emergency department summary tables. Jul 2022 [internet publication].Full text
3. Probst MA, Su E, Weiss RE, et al. Clinical Benefit of Hospitalization for Older Adults With Unexplained Syncope: A Propensity-Matched Analysis. Ann Emerg Med. 2019 Aug;74(2):260-69.Full text Abstract
4. Sarasin FP, Louis-Simonet M, Carballo D, et al. Prospective evaluation of patients with syncope: a population-based study. Am J Med. 2001 Aug 15;111(3):177-84. Abstract
5. D'Ascenzo F, Biondi-Zoccai G, Reed MJ, et al. Incidence, etiology and predictors of adverse outcomes in 43,315 patients presenting to the emergency department with syncope: an international meta-analysis. Int J Cardiol. 2013 Jul 15;167(1):57-62. Abstract
6. Francisco Pascual J, Jordan Marchite P, Rodríguez Silva J, et al. Arrhythmic syncope: from diagnosis to management. World J Cardiol. 2023 Apr 26;15(4):119-41.Full text Abstract
7. Longo S, Legramante JM, Rizza S, et al. Vasovagal syncope: an overview of pathophysiological mechanisms. Eur J Intern Med. 2023 Jun;112:6-14. Abstract
8. Sun BC, Hoffman JR, Mangione CM, et al. Older age predicts short-term, serious events after syncope. J Am Geriatr Soc. 2007 Jun;55(6):907-12.Full text Abstract
9. Grossman SA, Chiu D, Lipsitz L, et al. Can elderly patients without risk factors be discharged home when presenting to the emergency department with syncope? Arch Gerontol Geriatr. 2014 Jan-Feb;58(1):110-14.Full text Abstract
10. Gibson TA, Weiss RE, Sun BC. Predictors of Short-Term Outcomes after Syncope: A Systematic Review and Meta-Analysis. West J Emerg Med. 2018 May;19(3):517-23.Full text Abstract
11. Grubb BP, Karabin B. Syncope: evaluation and management in the geriatric patient. Clin Geriatr Med. 2012 Nov;28(4):717-28.Full text Abstract
12. Shen WK, Sheldon RS, Benditt DG, et al. 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society. Circulation. 2017 Aug 1;136(5):e60-122.Full text Abstract
13. National Institute for Health and Care Excellence. Heart valve disease presenting in adults: investigation and management. Nov 2021 [internet publication].Full text
14. Brignole M, Moya A, de Lange FJ, et al. 2018 ESC guidelines for the diagnosis and management of syncope. Eur Heart J. 2018 Jun 1;39(21):1883-948.Full text Abstract
15. Wang CZ. Current diagnosis and management of children with vasovagal syncope. World J Pediatr. 2007;3:98-103.
16. Mckee AC, Daneshvar DH. The neuropathology of traumatic brain injury. Handb Clin Neurol. 2015;127:45-66.Full text Abstract
17. Wiener Z, Shapiro NI, Chiu DT, et al. The prevalence of psychiatric disease in emergency department patients with unexplained syncope. Intern Emerg Med. 2013 Aug;8(5):427-30.Full text Abstract
18. Alciati A, Shiffer D, Dipaola F, et al. Psychogenic Pseudosyncope: Clinical Features, Diagnosis and Management. J Atr Fibrillation. 2020 Jun-Jul;13(1):2399.Full text Abstract
19. Arnar DO. Syncope in patients with structural heart disease. J Intern Med. 2013 Apr;273(4):336-44.Full text Abstract
20. Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021 Nov 30;144(22):e368-454.Full text Abstract
21. Erbel R, Aboyans V, Boileau C, et al. 2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the diagnosis and treatment of aortic diseases of the European Society of Cardiology (ESC). Eur Heart J. 2014 Nov 1;35(41):2873-926.Full text
22. Rushworth RL, Torpy DJ, Falhammar H. Adrenal Crisis. N Engl J Med. 2019 Aug 29;381(9):852-61.Full text Abstract
23. Calvo-Romero JM, Pérez-Miranda M, Bureo-Dacal P. Syncope in acute pulmonary embolism. Eur J Emerg Med. 2004 Aug;11(4):208-9. Abstract
24. Prandoni P, Lensing AW, Prins MH, et al. Prevalence of pulmonary embolism among patients hospitalized for syncope. N Engl J Med. 2016 Oct 20;375(16):1524-31.Full text Abstract
25. Oqab Z, Ganshorn H, Sheldon R. Prevalence of pulmonary embolism in patients presenting with syncope. A systematic review and meta-analysis. Am J Emerg Med. 2018 Apr;36(4):551-5. Abstract
26. Khan F, Tritschler T, Kahn SR, et al. Venous thromboembolism. Lancet. 2021 Jul 3;398(10294):64-77. Abstract
27. Timmons S, Kingston M, Hussain M, et al. Pulmonary embolism: differences in presentation between older and younger patients. Age Ageing. 2003 Nov;32(6):601-5.Full text Abstract
28. Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J. 2019 Sep;54(3).Full text Abstract
29. American College of Radiology. ACR appropriateness criteria: syncope. 2020 [internet publication].Full text
30. Grossman SA, Fischer C, Bar JL, et al. The yield of head CT in syncope: a pilot study. Intern Emerg Med. 2007 Mar;2(1):46-9.Full text Abstract
31. Mitsunaga MM, Yoon HC. Journal Club: Head CT scans in the emergency department for syncope and dizziness. AJR Am J Roentgenol. 2015 Jan;204(1):24-8.Full text Abstract
32. Brignole M, Moya A, de Lange FJ, et al. Practical Instructions for the 2018 ESC Guidelines for the diagnosis and management of syncope. Eur Heart J. 2018 Jun 1;39(21):e43-e80.Full text Abstract
33. Wieling W, Ganzeboom KS, Krediet CT, et al. Initial diagnostic strategy in the case of transient losses of consciousness: the importance of the medical history [in Dutch]. Ned Tijdschr Geneeskd. 2003 May 3;147(18):849-54. Abstract
34. Sheldon R, Rose S, Ritchie D, et al. Historical criteria that distinguish syncope from seizures. J Am Coll Cardiol. 2002 Jul 3;40(1):142-8.Full text Abstract
35. Asplund CA, O'Connor FG, Noakes TD. Exercise-associated collapse: an evidence-based review and primer for clinicians. Br J Sports Med. 2011 Nov;45(14):1157-62.Full text Abstract
36. Alboni P, Brignole M, Menozzi C, et al. Diagnostic value of history in patients with syncope with or without heart disease. J Am Coll Cardiol. 2001 Jun 1;37(7):1921-8.Full text Abstract
37. Brigo F, Nardone R, Bongiovanni LG. Value of tongue biting in the differential diagnosis between epileptic seizures and syncope. Seizure. 2012 Oct;21(8):568-72.Full text Abstract
38. Middlekauff HR, Stevenson WG, Stevenson LW, et al. Syncope in advanced heart failure: high risk of sudden death regardless of origin of syncope. J Am Coll Cardiol. 1993 Jan;21(1):110-6.Full text Abstract
39. Le RJ, Fenstad ER, Maradit-Kremers H, et al. Syncope in adults with pulmonary arterial hypertension. J Am Coll Cardiol. 2011 Aug 16;58(8):863-7. Abstract
40. Antzelevitch C, Brugada P, Brugada J, et al. Brugada syndrome: 1992-2002: a historical perspective. J Am Coll Cardiol. 2003 May 21;41(10):1665-71.Full text Abstract
41. Brugada J, Brugada R, Antzelevitch C, et al. Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. Circulation. 2002 Jan 1;105(1):73-8.Full text Abstract
42. Spirito P, Autore C, Rapezzi C, et al. Syncope and risk of sudden death in hypertrophic cardiomyopathy. Circulation. 2009 Apr 7;119(13):1703-10.Full text Abstract
43. Mascia G, Crotti L, Groppelli A, et al. Syncope in hypertrophic cardiomyopathy (part I): an updated systematic review and meta-analysis. Int J Cardiol. 2022 Jun 15;357:88-94. Abstract
44. Iglesias JF, Graf D, Forclaz A, et al. Stepwise evaluation of unexplained syncope in a large ambulatory population. Pacing Clin Electrophysiol. 2009 Mar;32 (Suppl 1):S202-6. Abstract
45. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr;21(2):69-72. Abstract
46. Gilani A, Juraschek SP, Belanger MJ, et al. Postural hypotension. BMJ. 2021 Apr 23;373:n922.
47. Dovgalyuk J, Holstege C, Mattu A, et al. The electrocardiogram in the patient with syncope. Am J Emerg Med. 2007 Jul;25(6):688-701. Abstract
48. Costantino G, Sun BC, Barbic F, et al. Syncope clinical management in the emergency department: a consensus from the first international workshop on syncope risk stratification in the emergency department. Eur Heart J. 2016 May 14;37(19):1493-8.Full text Abstract
49. Grossman SA, Fischer C, Lipsitz LA, et al. Predicting adverse outcomes in syncope. J Emerg Med. 2007 Oct;33(3):233-9.Full text Abstract
50. Bastani A, Su E, Adler DH, et al. Comparison of 30-Day Serious Adverse Clinical Events for Elderly Patients Presenting to the Emergency Department With Near-Syncope Versus Syncope. Ann Emerg Med. 2019 Mar;73(3):274-80.Full text Abstract
51. Grossman SA, Fischer C, Kancharla A, et al. Can benign etiologies predict benign outcomes in high-risk syncope patients? J Emerg Med. 2011 May;40(5):592-7. Abstract
52. Quinn JV, Stiell IG, McDermott DA, et al. Derivation of the San Francisco Syncope Rule to predict patients with short-term serious outcomes. Ann Emerg Med. 2004 Feb;43(2):224-32. Abstract
53. Rex DK, Boland CR, Dominitz JA, et al. Colorectal cancer screening: recommendations for physicians and patients from the U.S. Multi-Society Task Force on colorectal cancer. Am J Gastroenterol. 2017 Jul;112(7):1016-30.Full text Abstract
54. National Institute for Health and Care Excellence. Suspected cancer: recognition and referral. May 2025 [internet publication].Full text
55. National Institute for Health and Care Excellence. Quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary care. Aug 2023 [internet publication].Full text
56. Huff JS, Decker WW, Quinn JV, et al. Clinical policy: critical issues in the evaluation and management of adult patients presenting to the emergency department with syncope. Ann Emerg Med. 2007 Apr;49(4):431-44. Abstract
57. Ghani AR, Ullah W, Abdullah HMA, et al. The role of echocardiography in diagnostic evaluation of patients with syncope-a retrospective analysis. Am J Cardiovasc Dis. 2019;9(5):78-83.Full text Abstract
58. Primary Writing Committee., Sandhu RK, Raj SR, et al. Canadian Cardiovascular Society Clinical Practice Update on the Assessment and Management of Syncope. Can J Cardiol. 2020 Aug;36(8):1167-1177.Full text Abstract
59. Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022 May 3;145(18):e895-1032.Full text Abstract
60. Grobbee EJ, Wisse PHA, Schreuders EH, et al. Guaiac-based faecal occult blood tests versus faecal immunochemical tests for colorectal cancer screening in average-risk individuals. Cochrane Database Syst Rev. 2022 Jun 6;6(6):CD009276.Full text Abstract
61. Moss AJ. Long QT syndrome. JAMA. 2003 Apr 23-30;289(16):2041-4. Abstract
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