Summary
Definition
Myxoma is the most common cardiac tumour and constitutes 50% of all benign cardiac tumours in adults, but only 15% of such tumours in children. About 75% of primary cardiac tumours are benign. Most myxomas are found in the left atrium (75%) and, in decreasing frequencies, in the right atrium, right ventricle, and left ventricle. [Figure caption and citation for the preceding image starts]: Large left atrial myxomaFrom the collection of Dr Syed Wamique Yusuf, Department of Cardiology, University of Texas MD Anderson Cancer Center; used with permission [Citation ends].
[Figure caption and citation for the preceding image starts]: Macroscopic view of a left atrial myxomaR Al-Shahi Salman, D Northridge, ANJ Graham, R Grant. BMJ Case Reports 2009; doi:10.1136/bcr.09.2008.0875 [Citation ends].
History and exam
Key diagnostic factors
- presence of risk factors
- dyspnoea
- syncope
- dizziness
- CHF/pulmonary oedema
- embolic manifestations
- systolic or diastolic murmur
- tumour plop
Other diagnostic factors
- weight loss
- fatigue
- fever
- pallor
- arthralgia
- Raynaud's phenomenon
- loud first heart sound
- opening snap
- Carney's complex
- intra-cerebral aneurysm
Diagnostic investigations
Investigations to consider
- erythrocyte sedimentation rate
- C-reactive protein
- protein electrophoresis
- CT scan (chest)
- MRI scan (chest)
- biopsy
Treatment algorithm
Contributors
Authors
Syed Wamique Yusuf, MBBS, FRCPI
Professor of Medicine
Department of Cardiology
University of Texas MD Anderson Cancer Center
Houston
TX
Disclosures
SWY declares that he has no competing interests.
Acknowledgements
Dr Syed Wamique Yusuf would like to gratefully acknowledge the assistance of Dr Daniel J. Lenihan.
Disclosures
DJL declares that he has no competing interests.
Peer reviewers
Paul Heidenreich, MD
Associate Professor of Medicine
Stanford University
Stanford
CA
Disclosures
PH declares that he has no competing interests.
Richard Steingart, MD
Chief
Cardiology Service
Memorial Sloan-Kettering Cancer Center
New York
NY
Disclosures
RS declares that he has no competing interests.
Barry Kneale, MD, FRCP
Integrated Lead Cardiologist
Western Sussex Hospitals NHS Trust and Cardiac Department
Worthing Hospital
Worthing
UK
Disclosures
BK declares that he has no competing interests.
References
Key articles
Pinede L, Duhaut P, Loire R. Clinical presentation of left atrial cardiac myxoma. A series of 112 consecutive cases. Medicine (Baltimore). 2001 May;80(3):159-72. Abstract
Edwards A, Bermudez C, Piwonka G, et al. Carney's syndrome: complex myxomas. Report of four cases and review of the literature. Cardiovasc Surg. 2002 Jun;10(3):264-75. Abstract
Grossniklaus HE. McLean IW, Gillespie JJ. Bilateral eyelid myxomas in Carney's complex. Br J Ophthalmol. 1991 Apr;75(4):251-2.Full text Abstract
Ohara N, Komiya I, Yamauchi K, et al. Carney's complex with primary pigmented nodular adrenocortical disease and spotty pigmentations. Intern Med. 1993 Jan;32(1):60-2.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available here.
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