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Last reviewed: 22 Apr 2025
Last updated: 28 Nov 2023

Summary

Definition

History and exam

Key diagnostic factors

  • unconventional behaviour during history
  • emotional processing problems
  • recent psychological or physical stressors
  • remote life stressors
  • multiple illness behaviours
  • unusual neurological deficits
  • give-way weakness
  • inconsistent examination findings
  • paradoxical sensory findings
  • distractible symptoms
  • generalised seizure-like motor movements without loss of awareness
  • gait disorders
  • functional movement disorders

Other diagnostic factors

  • cognitive complaints
  • Hoover's sign
  • speech disturbance
  • swallowing disturbance
  • pseudoclonus
  • convergence spasm

Risk factors

  • history of sexual or physical abuse
  • adverse childhood events
  • history of trauma-related disorders
  • female sex
  • alexithymia
  • neuroticism
  • previously poor doctor-patient relationships

Diagnostic investigations

1st investigations to order

  • laboratory testing
  • electroencephalogram (EEG)

Investigations to consider

  • comprehensive neuropsychological testing
  • standardised personality testing
  • focused symptom inventories

Treatment algorithm

Contributors

Authors

Cynthia M. Stonnington, MD
Cynthia M. Stonnington

Professor of Psychiatry

Mayo Clinic

Scottsdale

AZ

Disclosures

CMS is an author of a number of references cited in this topic.

Erika Driver-Dunckley, MD
Erika Driver-Dunckley

Professor of Neurology

Mayo Clinic

Scottsdale

AZ

Disclosures

EDD declares that she has no competing interests.

Katherine H. Noe, MD, PhD
Katherine H. Noe

Associate Professor of Neurology

Mayo Clinic

Scottsdale

AZ

Disclosures

KHN declares that she has no competing interests.

Dona Locke, PhD
Dona Locke

Professor of Psychology

Mayo Clinic

Scottsdale

AZ

Disclosures

DL declares that she has no competing interests.

Peer reviewers

David Perez, MD, MMSc

Psychiatrist and Assistant Neurologist

Massachusetts General Hospital

Associate Professor of Neurology and Psychiatry

Harvard Medical School

Boston

MA

Disclosures

DLP has received honoraria for continuing medical education lectures in functional neurologic disorder, research funding for the NH and Sidney R. Baer Jr. Foundation, and royalties from Springer Nature for a textbook on functional movement disorder. DLP has also previously published with the BMJ and is on the editorial board of Epilepsy & Behavior. DLP is the author of a number of papers cited in this topic.

James L Levenson, MD

Rhona Arenstein Professor of Psychiatry

Virginia Commonwealth University

Virginia

Disclosures

JLL declares that he was the unpaid text editor for the sections of DSM 5 and DSM 5-TR covering the two diagnoses listed in the topic.

Anton Scamvougeras, MBChB, FRCP

Consultant Neuropsychiatrist and Associate Clinical Professor

Department of Psychiatry

University of British Columbia

Vancouver

British Columbia

Canada

Disclosures

AS declares that he has no competing interests. AS is the author of one paper cited in the topic.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Perez DL, Aybek S, Popkirov S, et al; American Neuropsychiatric Association Committee for Research. A review and expert opinion on the neuropsychiatric assessment of motor functional neurological disorders. J Neuropsychiatry Clin Neurosci. 2021 Winter;33(1):14-26.Full text  Abstract

Löwe B, Levenson J, Depping M, et al. Somatic symptom disorder: a scoping review on the empirical evidence of a new diagnosis. Psychol Med. 2022 Mar;52(4):632-48.Full text  Abstract

Stone J, Burton C, Carson A. Recognising and explaining functional neurological disorder. BMJ. 2020 Oct 21;371:m3745.

Bennett K, Diamond C, Hoeritzauer I, et al. A practical review of functional neurological disorder (FND) for the general physician. Clin Med (Lond). 2021 Jan;21(1):28-36.Full text  Abstract

den Boeft M, Claassen-van Dessel N, van der Wouden JC. How should we manage adults with persistent unexplained physical symptoms? BMJ. 2017 Feb 8;356:j268. Abstract

Henningsen P, Zipfel S, Herzog W. Management of functional somatic syndromes. Lancet. 2007 Mar 17;369(9565):946-55. Abstract

Reference articles

A full list of sources referenced in this topic is available here.

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