Evidence
This page contains a snapshot of featured content which highlights evidence addressing key clinical questions including areas of uncertainty. Please see the main topic reference list for details of all sources underpinning this topic.
BMJ Best Practice evidence tables
Evidence tables provide easily navigated layers of evidence in the context of specific clinical questions, using GRADE and a BMJ Best Practice Effectiveness rating. Follow the links at the bottom of the table, which go to the related evidence score in the main topic text, providing additional context for the clinical question. Find out more about our evidence tables.
This table is a summary of the analysis reported in a guideline (underpinned by a systematic review) that focuses on the above important clinical question.
Confidence in the evidence is very low or low where GRADE has been performed and there may be no difference in effectiveness between the intervention and comparison for most outcomes. However, this is uncertain and new evidence could change this in the future.
Population: Women with RPL and hereditary thrombophilia
Intervention: Low molecular weight heparin (LMWH)
Comparison: No treatment
| Outcome | Effectiveness (BMJ rating)? | Confidence in evidence (GRADE)? |
|---|---|---|
Live birth rate (prior early pregnancy loss) | No statistically significant difference | Low |
Live birth rate (prior late pregnancy loss) | No statistically significant difference | Low |
Recommendations as stated in the source guideline For women with hereditary thrombophilia and a history of RPL, we suggest not using antithrombotic prophylaxis unless in the context of research, or if indicated for VTE prevention.
Note Conditional recommendation based on finding “no evidence of a beneficial effect of anticoagulant treatment in women with RPL and hereditary thrombophilia”.
This evidence table is related to the following section/s:
Cochrane Clinical Answers
Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.
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