Epidemiology

AUB is common and affects women worldwide. AUB and heavy menstrual bleeding (HMB) are common conditions affecting 14% to 25% of women of reproductive age.[5][6]

A US population-based survey of women ages 18 to 50 years reported an annual prevalence rate of 53 per 1000 women.[7] AUB is the fourth most common reason for referral to UK gynecologic services.[8] Variation in menstrual flow and cycle length are common at the extremes of reproductive age (during early teenage years and preceding menopause). 

Annually, 1 million UK women seek help for HMB, and an estimated 3.5 million work days are lost.[6] 

A national 4-year Royal College of Obstetricians and Gynaecologists' audit of HMB in the UK found that 43% of women received surgery within a year of their first attendance at hospital.[9] Considering 47% of all UK-born babies are to women aged ≥30, fertility-ending surgery is frequently unacceptable.[10]

There is an unmet clinical need in managing women with HMB.

Use of this content is subject to our disclaimer