Cellulitis is a common condition. The Global Burden of Disease project estimated that 56 million cases of cellulitis (678.4 per 100,000 population) occurred in 2021, causing 28,900 deaths.[3]Institute For Health Metrics and Evaluation. Global health metrics: cellulitis - level 4 cause. 2021 [internet publication].
https://www.healthdata.org/research-analysis/diseases-injuries-risks/factsheets/2021-cellulitis-level-4-disease
Sex does not affect the rate, but increasing age is associated with a higher incidence.[3]Institute For Health Metrics and Evaluation. Global health metrics: cellulitis - level 4 cause. 2021 [internet publication].
https://www.healthdata.org/research-analysis/diseases-injuries-risks/factsheets/2021-cellulitis-level-4-disease
[4]Mcnamara DR, Tleyjeh IM, Berbari EF, et al. Incidence of lower-extremity cellulitis: a population-based study in Olmsted County, Minnesota. Mayo Clin Proc. 2007 Jul;82(7):817-21.
http://www.ncbi.nlm.nih.gov/pubmed/17605961?tool=bestpractice.com
In one study over a 12-month period from 2014 to 2015, the cellulitis hospitalization rate was 1100 per 100,000 in people ages 80 years and over, as opposed to 237 episodes per 100,000 in the general population.[5]Kumar M, Jong Ngian VJ, Yeong C, et al. Cellulitis in older people over 75 years - are there differences? Ann Med Surg (Lond). 2020 Jan;49:37-40.
https://www.sciencedirect.com/science/article/pii/S2049080119301803?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/31867103?tool=bestpractice.com
Admissions for cellulitis consistently peak in summer months, with this seasonality observed in several countries.[6]Peterson RA, Polgreen LA, Cavanaugh JE, et al. Increasing incidence, cost, and seasonality in patients hospitalized for cellulitis. Open Forum Infect Dis. 2017 Winter;4(1):ofx008.
https://academic.oup.com/ofid/article/4/1/ofx008/2978056
http://www.ncbi.nlm.nih.gov/pubmed/28480281?tool=bestpractice.com
[7]Hsu RJ, Chou CC, Liu JM, et al. The association of cellulitis incidence and meteorological factors in Taiwan. Epidemiol Infect. 2019 Jan;147:e138.
https://www.cambridge.org/core/journals/epidemiology-and-infection/article/association-of-cellulitis-incidence-and-meteorological-factors-in-taiwan/1F6217953A0A5052F8AC4FFA1D9C4782
http://www.ncbi.nlm.nih.gov/pubmed/30869041?tool=bestpractice.com
[8]Manning L, Cannon J, Dyer J, et al. Seasonal and regional patterns of lower leg cellulitis in Western Australia. Intern Med J. 2019 Feb;49(2):212-6.
https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14034
http://www.ncbi.nlm.nih.gov/pubmed/29984905?tool=bestpractice.com
Since the early 2000’s there has been an increase in visits for skin infection with community-associated MRSA; however, further analysis concluded this was mostly due to abscesses rather than cellulitis.[9]Kaye KS, Petty LA, Shorr AF, et al. Current epidemiology, etiology, and burden of acute skin infections in the United States. Clin Infect Dis. 2019 Apr 8;68(suppl 3):S193-9.
https://academic.oup.com/cid/article/68/Supplement_3/S193/5428806
http://www.ncbi.nlm.nih.gov/pubmed/30957165?tool=bestpractice.com
[10]Pallin DJ, Egan DJ, Pelletier AJ, et al. Increased US emergency department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin-resistant Staphylococcus aureus. Ann Emerg Med. 2008 Mar;51(3):291-8.
http://www.ncbi.nlm.nih.gov/pubmed/18222564?tool=bestpractice.com
[11]Qualls ML, Mooney MM, Camargo CA Jr, et al. Emergency department visit rates for abscess versus other skin infections during the emergence of community-associated methicillin-resistant Staphylococcus aureus, 1997-2007. Clin Infect Dis. 2012 Jul;55(1):103-5.
http://cid.oxfordjournals.org/content/55/1/103.long
http://www.ncbi.nlm.nih.gov/pubmed/22460965?tool=bestpractice.com