A broad-spectrum benzimidazole that is currently being used in cows and pigs. It has been investigated in humans in phase 1 studies.[69]An G, Murry DJ, Gajurel K, et al. Pharmacokinetics, safety, and tolerability of oxfendazole in healthy volunteers: a randomized, placebo-controlled first-in-human single-dose escalation study. Antimicrob Agents Chemother. 2019 Apr;63(4):e02255-18.
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[70]Bach T, Galbiati S, Kennedy JK, et al. Pharmacokinetics, safety, and tolerability of oxfendazole in healthy adults in an open-label phase 1 multiple ascending dose and food effect study. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01018-20.
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One phase 2/3 study in patients with mild parenchymal brain cysticercosis is planned.[71]ClinicalTrials.gov. Oxfendazole in mild parenchymal brain cysticercosis. ClinicalTrials.gov Identifier: NCT06565507. Nov 2024 [internet publication].
https://clinicaltrials.gov/study/NCT06565507