Epidemiology
Mitral valve prolapse is the most common cause of chronic mitral regurgitation in the US.[1][2] According to current diagnostic criteria, the prevalence in the US is estimated at 2.4% with equal male and female distribution.[14] The risk of complications is greater in men and in people over 45 years old.[15] Older echocardiographic studies used referral-based clinical studies and less-specific criteria for definition. Selection bias led to false high incidence figures up to 38% in some population groups.[9]
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