In general, viral bronchiolitis is a mild condition that is self-limited and resolves within a few days.
However, studies have demonstrated that a significant proportion of infants with respiratory syncytial virus bronchiolitis go on to develop recurrent wheezing; and rhinovirus has been increasingly studied and shown to have an association with recurrent wheezing and a diagnosis of asthma.[144]Mansbach JM, Camargo CA Jr. Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma. Clin Lab Med. 2009 Dec;29(4):741-55.
http://www.ncbi.nlm.nih.gov/pubmed/19892232?tool=bestpractice.com
[145]Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008;178:667-72.
https://www.atsjournals.org/doi/full/10.1164/rccm.200802-309OC
http://www.ncbi.nlm.nih.gov/pubmed/18565953?tool=bestpractice.com
[146]Lukkarinen M, Koistinen A, Turunen R, et al. Rhinovirus-induced first wheezing episode predicts atopic but not nonatopic asthma at school age. J Allergy Clin Immunol. 2017 Oct;140(4):988-95.
http://www.ncbi.nlm.nih.gov/pubmed/28347734?tool=bestpractice.com
[147]Törmänen S, Lauhkonen E, Riikonen R, et al. Risk factors for asthma after infant bronchiolitis. Allergy. 2018 Apr;73(4):916-22.
http://www.ncbi.nlm.nih.gov/pubmed/29105099?tool=bestpractice.com
[148]Midulla F, Nicolai A, Ferrara M, et al. Recurrent wheezing 36 months after bronchiolitis is associated with rhinovirus infections and blood eosinophilia. Acta Paediatr. 2014 Oct;103(10):1094-9.
http://www.ncbi.nlm.nih.gov/pubmed/24948158?tool=bestpractice.com
Risk factors such as family history of asthma increase the risk of a future asthma diagnosis.[145]Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008;178:667-72.
https://www.atsjournals.org/doi/full/10.1164/rccm.200802-309OC
http://www.ncbi.nlm.nih.gov/pubmed/18565953?tool=bestpractice.com
[149]Brandão HV, Vieira GO, Vieira TO, et al. Acute viral bronchiolitis and risk of asthma in schoolchildren: analysis of a Brazilian newborn cohort. J Pediatr (Rio J). 2017 May - Jun;93(3):223-9.
https://www.sciencedirect.com/science/article/pii/S002175571630119X?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/27665269?tool=bestpractice.com
One large retrospective population-based study from Spain found the rate of recurrent wheezing or asthma to be higher when bronchiolitis occurred after the first 6 months of life.[150]Muñoz-Quiles C, López-Lacort M, Díez-Domingo J, et al. Bronchiolitis, regardless of its etiology and severity, is associated with increased risk of asthma: a population-based study. J Infect Dis. 2023 Oct 3;228(7):840-50.
https://academic.oup.com/jid/article/228/7/840/7104078
http://www.ncbi.nlm.nih.gov/pubmed/37015894?tool=bestpractice.com