One systematic review and meta-analysis reported a global pooled prevalence rate of 1.44% for amblyopia.[7]Fu Z, Hong H, Su Z, et al. Global prevalence of amblyopia and disease burden projections through 2040: a systematic review and meta-analysis. Br J Ophthalmol. 2020 Aug;104(8):1164-70.
http://www.ncbi.nlm.nih.gov/pubmed/31704700?tool=bestpractice.com
Prevalence was highest in Europe (2.9%) and North America (2.41%), with lower rates reported in Asia (1.09%) and Africa (0.72%).[7]Fu Z, Hong H, Su Z, et al. Global prevalence of amblyopia and disease burden projections through 2040: a systematic review and meta-analysis. Br J Ophthalmol. 2020 Aug;104(8):1164-70.
http://www.ncbi.nlm.nih.gov/pubmed/31704700?tool=bestpractice.com
No gender disparity was identified. By 2040, a projected 221.9 million people worldwide will be living with amblyopia.[7]Fu Z, Hong H, Su Z, et al. Global prevalence of amblyopia and disease burden projections through 2040: a systematic review and meta-analysis. Br J Ophthalmol. 2020 Aug;104(8):1164-70.
http://www.ncbi.nlm.nih.gov/pubmed/31704700?tool=bestpractice.com
In the US, population-based studies of preschool children report an amblyopia prevalence of approximately 2%, with a higher prevalence among Hispanic/Latino than African-American children (2.6% vs. 1.5%, respectively).[4]Multi-ethnic Pediatric Eye Disease Study Group. Prevalence of amblyopia and strabismus in African American and Hispanic children ages 6 to 72 months: the multi-ethnic pediatric eye disease study. Ophthalmology. 2008 Jul;115(7):1229-36.e1.
http://www.ncbi.nlm.nih.gov/pubmed/17953989?tool=bestpractice.com
[8]Friedman DS, Repka MX, Katz J, et al. Prevalence of amblyopia and strabismus in white and African American children aged 6 through 71 months the Baltimore Pediatric Eye Disease Study. Ophthalmology. 2009 Nov;116(11):2128-34.e1-2.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2783780
http://www.ncbi.nlm.nih.gov/pubmed/19762084?tool=bestpractice.com
Uncorrectable vision attributable to unilateral or bilateral amblyopia has been reported in 4% of older US children and adolescents (ages 12-19 years).[9]Fazal O, Slopen N, Galbraith AA, et al. Sociodemographic disparities in uncorrectable visual impairment among US adolescents. Am J Ophthalmol. 2025 May;273:248-54.
http://www.ncbi.nlm.nih.gov/pubmed/40010421?tool=bestpractice.com
Significant socioeconomic factors included family income below the poverty level, Mexican or non-Hispanic black ethnicity, food insecurity, caregiver education status below high school, and absence of private insurance.[9]Fazal O, Slopen N, Galbraith AA, et al. Sociodemographic disparities in uncorrectable visual impairment among US adolescents. Am J Ophthalmol. 2025 May;273:248-54.
http://www.ncbi.nlm.nih.gov/pubmed/40010421?tool=bestpractice.com