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Last reviewed: 26 Jul 2025
Last updated: 28 Jan 2025

Summary

Definition

History and exam

Other diagnostic factors

  • light-headedness/dizziness
  • postural/orthostatic hypotension
  • dysphagia
  • odynophagia
  • pain
  • melena
  • hematochezia
  • shock
  • signs of anemia

Risk factors

  • condition predisposing to retching, vomiting, and/or straining
  • chronic cough
  • hiatus hernia
  • retching during endoscopy or other instrumentation
  • significant alcohol use
  • previous instrumentation
  • age 30 to 50 years
  • male sex
  • use of aspirin or other nonsteroidal anti-inflammatory drugs
  • hiccups
  • blunt abdominal trauma
  • cardiopulmonary resuscitation

Diagnostic tests

1st tests to order

  • CBC
  • BUN
  • creatinine and electrolytes
  • LFT
  • prothrombin time (PT)/INR
  • PTT
  • crossmatching/blood grouping
  • flexible esophagogastroduodenoscopy (EGD)

Tests to consider

  • CT chest
  • CXR
  • angiography

Treatment algorithm

Contributors

Authors

Professor of Medicine

Center Director

Center for Advanced Therapeutic Endoscopy (CATE)

Advent Health

Porter Adventist Hospital

Denver

CO

Disclosures

DGA is a consultant for Merit Medical, Cook Endoscopy, Olympus America, and Boston Scientific.

Dr Douglas Adler would like to gratefully acknowledge Dr Shilpa Reddy and Dr Juan Carlos Munoz, the previous contributors to this topic.

Disclosures

SR and JCM declare that they have no competing interests.

Peer reviewers

Professor of Medicine

Department of Medicine and Therapeutics

Director

Institute of Digestive Disease

The Chinese University of Hong Kong

Hong Kong

Disclosures

JS declares that he has no competing interests.

Consultant Gastroenterologist

Sandwell General Hospital

Lyndon

West Bromwich

UK

Disclosures

IM declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Alali AA, Barkun AN. An update on the management of non-variceal upper gastrointestinal bleeding. Gastroenterol Rep (Oxf). 2023 Mar 20;11:goad011.Full text  Abstract

Laine L, Barkun AN, Saltzman JR, et al. ACG clinical guideline: upper gastrointestinal and ulcer bleeding. Am J Gastroenterol. 2021 May 1;116(5):899-917.Full text  Abstract

Barkun AN, Almadi M, Kuipers EJ, et al. Management of nonvariceal upper gastrointestinal bleeding: guideline recommendations from the International Consensus Group. Ann Intern Med. 2019 Dec 3;171(11):805-22.Full text  Abstract

American College of Radiology. ACR appropriateness criteria: nonvariceal upper gastrointestinal bleeding​. 2024 [internet publication].Full text

Reference articles

A full list of sources referenced in this topic is available here.

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