References

Key articles

National Institute for Health and Care Excellence. Pancreatitis. Dec 2020 [internet publication].Full text

Tenner S, Vege S, Sheth S, et al. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2024 Mar 119(3):419-37.Full text  Abstract

Leppäniemi A, Tolonen M, Tarasconi A, et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg. 2019 Jun 13;14:27.Full text  Abstract

Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 2013 Jul-Aug;13(4 suppl 2):e1-15. Abstract

Crockett SD, Wani S, Gardner TB, et al. American Gastroenterological Association Institute guideline on initial management of acute pancreatitis. Gastroenterology. 2018 Mar;154(4):1096-101. Abstract

Reference articles

1. Nirula R. Chapter 9: Diseases of the pancreas. High yield surgery. Philadelphia, PA: Lippincott Williams & Wilkins; 2000.

2. Banks PA, Bollen TL, Dervenis C, et al; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis - 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013 Jan;62(1):102-11.Full text  Abstract

3. Balthazar EJ, Robinson DL, Megibow AJ, et al. Acute pancreatitis: value of CT in establishing prognosis. Radiology. 1990 Feb;174(2):331-6. Abstract

4. Doherty GM, Meko JB, Olson JA, et al. Chapter 17: Pancreas. In: The Washington manual of surgery. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1999.

5. Way LW, Doherty GM. Chapter 27: Pancreas. In: Current surgical diagnosis & treatment. 11th ed. New York, NY: McGraw-Hill; 2003.

6. Raghu MG, Wig JD, Kochhar R, et al. Lung complications in acute pancreatitis. JOP. 2007 Mar 10;8(2):177-85.Full text  Abstract

7. Boxhoorn L, Voermans RP, Bouwense SA, et al. Acute pancreatitis. Lancet. 2020 Sep 5;396(10252):726-34. Abstract

8. National Institute for Health and Care Excellence. Pancreatitis. Dec 2020 [internet publication].Full text

9. Tenner S, Vege S, Sheth S, et al. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2024 Mar 119(3):419-37.Full text  Abstract

10. Kingsnorth A, O'Reilly D. Acute pancreatitis. BMJ. 2006 May 6;332(7549):1072-6.Full text  Abstract

11. Xiao AY, Tan ML, Wu LM, et al. Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies. Lancet Gastroenterol Hepatol. 2016 Sep;1(1):45-55. Abstract

12. Li CL, Jiang M, Pan CQ, et al. The global, regional, and national burden of acute pancreatitis in 204 countries and territories, 1990-2019. BMC Gastroenterol. 2021 Aug 25;21(1):332.Full text  Abstract

13. Munoz A, Katerndahl DA. Diagnosis and management of acute pancreatitis. Am Fam Physician. 2000 Jul 1;62(1):164-74.Full text  Abstract

14. Whitcomb DC. Clinical practice: acute pancreatitis. N Engl J Med. 2006 May 18;354(20):2142-50. Abstract

15. Brunicardi FC, Andersen DK, Billiar TR. Chapter 32: Pancreas. In: Schwartz's principles of surgery. 8th ed. New York, NY: McGraw-Hill; 2005.

16. Badalov N, Baradarian R, Iswara K, et al. Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol. 2007 Mar 28;5(6):648-61; quiz 644.Full text  Abstract

17. Juang P, Page RL, Zolty R. Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. Ann Pharmacother. 2006 Jan;40(1):128-34. Abstract

18. Underwood TW, Frye CB. Drug-induced pancreatitis. Clin Pharm. 1993 Jun;12(6):440-8. Abstract

19. Gelrud A, Sheth S, Banerjee S, et al. Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis. Am J Gastroenterol. 2004 Aug;99(8):1557-62. Abstract

20. Maxson CJ, Greenfield SM, Turner JL. Acute pancreatitis as a common complication of 2',3'-dideoxyinosine therapy in the acquired immunodeficiency syndrome. Am J Gastroenterol. 1992 Jun;87(6):708-13. Abstract

21. Tenner S. Drug induced acute pancreatitis: does it exist? World J Gastroenterol. 2014 Nov 28;20(44):16529-34.Full text  Abstract

22. Sah RP, Saluja A. Molecular mechanisms of pancreatic injury. Curr Opin Gastroenterol. 2011 Sep;27(5):444-51.Full text  Abstract

23. Townsend C. Chapter 53: exocrine pancreas. In: Sabiston textbook of surgery board review. 17th ed. Philadelphia, PA: Saunders; 2004.

24. Carr RA, Rejowski BJ, Cote G2, et al. Systematic review of hypertriglyceridemia-induced acute pancreatitis: A more virulent etiology? Pancreatology. 2016 Jul-Aug;16(4):469-76. Abstract

25. Leppäniemi A, Tolonen M, Tarasconi A, et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg. 2019 Jun 13;14:27.Full text  Abstract

26. Bálint ER, Fűr G, Kiss L, et al. Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis. Sci Rep. 2020 Oct 21;10(1):17936.Full text  Abstract

27. Saini J, Marino D, Badalov N, et al. Drug-induced acute pancreatitis: an evidence-based classification (revised). Clin Transl Gastroenterol. 2023 Aug 1;14(8):e00621.Full text  Abstract

28. Akshintala VS, Sperna Weiland CJ, Bhullar FA, et al. Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol. 2021 Sep;6(9):733-42. Abstract

29. Akbar A, Abu Dayyeh BK, Baron TH, et al. Rectal nonsteroidal anti-inflammatory drugs are superior to pancreatic duct stents in preventing pancreatitis after endoscopic retrograde cholangiopancreatography: a network meta-analysis. Clin Gastroenterol Hepatol. 2013 Jul;11(7):778-83. Abstract

30. Yaghoobi M, Rolland S, Waschke KA, et al. Meta-analysis: rectal indomethacin for the prevention of post-ERCP pancreatitis. Aliment Pharmacol Ther. 2013 Nov;38(9):995-1001.Full text  Abstract

31. Elmunzer BJ, Higgins PD, Saini SD, et al; United States Cooperative for Outcomes Research in Endoscopy. Does rectal indomethacin eliminate the need for prophylactic pancreatic stent placement in patients undergoing high-risk ERCP? Post hoc efficacy and cost-benefit analyses using prospective clinical trial data. Am J Gastroenterol. 2013 Mar;108(3):410-5.Full text  Abstract

32. Wu D, Wan J, Xia L, et al. The efficiency of aggressive hydration with lactated ringer solution for the prevention of post-ERCP pancreatitis: a systematic review and meta-analysis. J Clin Gastroenterol. 2017 Sep;51(8):e68-76. Abstract

33. Zhang ZF, Duan ZJ, Wang LX, et al. Aggressive hydration with lactated Ringer solution in prevention of postendoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis of randomized controlled trials. J Clin Gastroenterol. 2017 Mar;51(3):e17-26. Abstract

34. Dumonceau JM, Kapral C, Aabakken L, et al. ERCP-related adverse events: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2020 Feb;52(2):127-49.Full text  Abstract

35. Cho IR, Han KD, Lee SH, et al. Association between glycemic status and the risk of acute pancreatitis: a nationwide population-based study. Diabetol Metab Syndr. 2023 May 19;15(1):104.Full text  Abstract

36. Aune D, Mahamat-Saleh Y, Norat T, et al. Diabetes mellitus and the risk of pancreatitis: a systematic review and meta-analysis of cohort studies. Pancreatology. 2020 Jun;20(4):602-7. Abstract

37. Frick TW, Wiegand D, Bimmler D, et al. A rat model to study hypercalcemia-induced acute pancreatitis. Int J Pancreatol. 1994 Apr;15(2):91-6. Abstract

38. Frick TW, Spycher MA, Heitz PU, et al. Hypercalcaemia and pancreatic ultrastructure in cats. Eur J Surg. 1992 May;158(5):289-94. Abstract

39. Rawla P, Bandaru SS, Vellipuram AR. Review of infectious etiology of acute pancreatitis. Gastroenterology Res. 2017 Jun;10(3):153-8.Full text  Abstract

40. Kojima M, Sipos B, Klapper W, et al. Autoimmune pancreatitis: frequency, IgG4 expression, and clonality of T and B cells. Am J Surg Pathol. 2007 Apr;31(4):521-8. Abstract

41. Kobayashi S, Yoshida M, Kitahara T, et al. Autoimmune pancreatitis as the initial presentation of systemic lupus erythematosus. Lupus. 2007;16(2):133-6. Abstract

42. Heyries L, Barthet M, Delvasto C, et al. Long-term results of endoscopic management of pancreas divisum with recurrent acute pancreatitis. Gastrointest Endosc. 2002 Mar;55(3):376-81. Abstract

43. Strand DS, Law RJ, Yang D, et al. AGA clinical practice update on the endoscopic approach to recurrent acute and chronic pancreatitis: Expert Review. Gastroenterology. 2022 Oct;163(4):1107-14.Full text  Abstract

44. Spicak J. Etiological factors of acute pancreatitis [in Czech]. Vnitr Lek. 2002 Sep;48(9):829-41. Abstract

45. Guda NM, Muddana V, Whitcomb DC, et al. Recurrent acute pancreatitis: international state-of-the-science conference with recommendations. Pancreas. 2018 Jul;47(6):653-66. Abstract

46. Vitone LJ, Greenhalf W, Howes NR, et al. Hereditary pancreatitis and secondary screening for early pancreatic cancer. Rocz Akad Med Bialymst. 2005;50:73-84. Abstract

47. Whitcomb DC. Genetic risk factors for pancreatic disorders. Gastroenterology. 2013 Jun;144(6):1292-302.Full text  Abstract

48. Whitcomb DC. Genetic aspects of pancreatitis. Annu Rev Med. 2010;61:413-24. Abstract

49. Giefer MJ, Lowe ME, Werlin SL, et al. Early-onset acute recurrent and chronic pancreatitis is associated with PRSS1 or CTRC gene mutations. J Pediatr. 2017 Jul;186:95-100.Full text  Abstract

50. van Dijk SM, Hallensleben NDL, van Santvoort HC, et al. Acute pancreatitis: recent advances through randomised trials. Gut. 2017 Nov;66(11):2024-32. Abstract

51. Márta K, Gede N, Szakács Z, et al. Combined use of indomethacin and hydration is the best conservative approach for post-ERCP pancreatitis prevention: a network meta-analysis. Pancreatology. 2021 Oct;21(7):1247-55.Full text  Abstract

52. Buxbaum JL, Freeman M, Amateau SK, et al. American Society for Gastrointestinal Endoscopy guideline on post-ERCP pancreatitis prevention strategies: summary and recommendations. Gastrointest Endosc. 2023 Feb;97(2):153-62.

53. Buxbaum J, Yan A, Yeh K, et al. Aggressive hydration with lactated Ringer's solution reduces pancreatitis after endoscopic retrograde cholangiopancreatography. Clin Gastroenterol Hepatol. 2014 Feb;12(2):303-7.Full text  Abstract

54. Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 2013 Jul-Aug;13(4 suppl 2):e1-15. Abstract

55. Kumari R, Sadarat F, Luhana S, et al. Evaluating the efficacy of different volume resuscitation strategies in acute pancreatitis patients: a systematic review and meta-analysis. BMC Gastroenterol. 2024 Mar 25;24(1):119.Full text  Abstract

56. Johnson CD, Besselink MG, Carter R. Acute pancreatitis. BMJ. 2014 Aug 12;349:g4859. Abstract

57. Larvin M. Assessment of severity and prognosis in acute pancreatitis. Eur J Gastroenterol Hepatol. 1997 Feb;9(2):122-30. Abstract

58. Tenner S. Initial management of acute pancreatitis: critical issues during the first 72 hours. Am J Gastroenterol. 2004 Dec;99(12):2489-94. Abstract

59. Papachristou GI, Muddana V, Yadav D, et al. Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis. Am J Gastroenterol. 2010 Feb;105(2):435-41. Abstract

60. Capurso G, Ponz de Leon Pisani R, Lauri G, et al. Clinical usefulness of scoring systems to predict severe acute pancreatitis: a systematic review and meta-analysis with pre and post-test probability assessment. United European Gastroenterol J. 2023 Nov;11(9):825-36.Full text  Abstract

61. Kesavan CR, Pitchumoni CS, Marino WD. Acute painless pancreatitis as a rare complication in Legionnaires disease. Am J Gastroenterol. 1993 Mar;88(3):468-9.

62. Lankisch PG, Müller CH, Niederstadt H, et al. Painless acute pancreatitis subsequent to anticholinesterase insecticide (parathion) intoxication. Am J Gastroenterol. 1990 Jul;85(7):872-5. Abstract

63. Ammann RW. The natural history of alcoholic chronic pancreatitis. Intern Med. 2001 May;40(5):368-75.Full text  Abstract

64. Hines OJ, Pandol SJ. Management of severe acute pancreatitis. BMJ. 2019 Dec 2;367:l6227. Abstract

65. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10.Full text  Abstract

66. Burland L, Green BL. A cutaneous manifestation of intra-abdominal disease. BMJ. 2014 Sep 17;349:g5492.Full text  Abstract

67. Rompianesi G, Hann A, Komolafe O, et al. Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis. Cochrane Database Syst Rev. 2017 Apr 21;(4):CD012010.Full text  Abstract

68. Brown A, Orav J, Banks PA. Hemoconcentration is an early marker for organ failure and necrotizing pancreatitis. Pancreas. 2000 May;20(4):367-72. Abstract

69. McPherson RA, Pincus MR. Henry's clinical diagnosis and management by laboratory methods. 21st ed. Philadelphia, PA: Saunders; 2006.

70. Khanna AK, Meher S, Prakash S, et al. Comparison of Ranson, Glasgow, MOSS, SIRS, BISAP, APACHE-II, CTSI scores, IL-6, CRP, and procalcitonin in predicting severity, organ failure, pancreatic necrosis, and mortality in acute pancreatitis. HPB Surg. 2013;2013:367581.Full text  Abstract

71. Komolafe O, Pereira SP, Davidson BR, et al. Serum C-reactive protein, procalcitonin, and lactate dehydrogenase for the diagnosis of pancreatic necrosis. Cochrane Database Syst Rev. 2017 Apr 21;(4):CD012645.Full text  Abstract

72. Freeman ML, Werner J, van Santvoort HC, et al. Interventions for necrotizing pancreatitis: summary of a multidisciplinary consensus conference. Pancreas. 2012 Nov;41(8):1176-94. Abstract

73. Moolla Z, Anderson F, Thomson SR. Use of amylase and alanine transaminase to predict acute gallstone pancreatitis in a population with high HIV prevalence. World J Surg. 2013 Jan;37(1):156-61.Full text  Abstract

74. Liu CL, Fan ST, Lo CM, et al. Clinico-biochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography. Aliment Pharmacol Ther. 2005 Sep 1;22(5):423-31.Full text  Abstract

75. Tenner S, Dubner H, Steinberg W. Predicting gallstone pancreatitis with laboratory parameters: a meta-analysis. Am J Gastroenterol. 1994 Oct;89(10):1863-6. Abstract

76. Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet. 2008 Jan 12;371(9607):143-52. Abstract

77. American Gastroenterological Association. AGA Institute medical position statement on acute pancreatitis. Gastroenterology. 2007 May;132(5):2019-21. Abstract

78. Rogers P, Adlan T, Page G. Non-invasive imaging in pancreatitis. BMJ. 2014 Aug 28;349:g5223.Full text  Abstract

79. Fleszler F, Friedenberg F, Krevsky B, et al. Abdominal computed tomography prolongs length of stay and is frequently unnecessary in the evaluation of acute pancreatitis. Am J Med Sci. 2003 May;325(5):251-5. Abstract

80. Spanier BW, Nio Y, van der Hulst RW, et al. Practice and yield of early CT scan in acute pancreatitis: a Dutch observational multicenter study. Pancreatology. 2010 May 17;10(2-3):222-8. Abstract

81. Wan J, Ouyang Y, Yu C, et al. Comparison of EUS with MRCP in idiopathic acute pancreatitis: a systematic review and meta-analysis. Gastrointest Endosc. 2017 Dec 7;87(5):1180-8.e9.Full text  Abstract

82. Wilcox CM, Varadarajulu S, Eloubeidi M. Role of endoscopic evaluation in idiopathic pancreatitis: a systematic review. Gastrointest Endosc. 2006 Jun;63(7):1037-45. Abstract

83. Stimac D, Miletić D, Radić M, et al. The role of nonenhanced magnetic resonance imaging in the early assessment of acute pancreatitis. Am J Gastroenterol. 2007 Mar 22;102(5):997-1004. Abstract

84. American College of Radiology. ACR appropriateness criteria: acute pancreatitis. 2019 [internet publication].Full text

85. Chang K, Lu W, Zhang K, et al. Rapid urinary trypsinogen-2 test in the early diagnosis of acute pancreatitis: a meta-analysis. Clin Biochem. 2012 May 7;45(13-14):1051-6. Abstract

86. Aoun E, Chen J, Reighard D, et al. Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysis. Pancreatology. 2009;9(6):777-85. Abstract

87. Zhang J, Niu J, Yang J. Interleukin-6, interleukin-8 and interleukin-10 in estimating the severity of acute pancreatitis: an updated meta-analysis. Hepatogastroenterology. 2014 Jan-Feb;61(129):215-20. Abstract

88. Siriwardena AK, Jegatheeswaran S, Mason JM, et al. A procalcitonin-based algorithm to guide antibiotic use in patients with acute pancreatitis (PROCAP): a single-centre, patient-blinded, randomised controlled trial. Lancet Gastroenterol Hepatol. 2022 Oct;7(10):913-21. Abstract

89. Ranson JH, Pasternack BS. Statistical methods for quantifying the severity of clinical acute pancreatitis. J Surg Res. 1977 Feb;22(2):79-91. Abstract

90. Tran DD, Cuesta MA. Evaluation of severity in patients with acute pancreatitis. Am J Gastroenterol. 1992 May;87(5):604-8. Abstract

91. Wang SQ, Li SJ, Feng QX, et al. Overweight is an additional prognostic factor in acute pancreatitis: a meta-analysis. Pancreatology. 2011 May 17;11(2):92-8. Abstract

92. Johnson CD, Abu-Hilal M. Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut. 2004 Sep;53(9):1340-4.Full text  Abstract

93. Lytras D, Manes K, Triantopoulou C, et al. Persistent early organ failure: defining the high-risk group of patients with severe acute pancreatitis? Pancreas. 2008 Apr;36(3):249-54. Abstract

94. Buter A, Imrie CW, Carter CR, et al. Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis. Br J Surg. 2002 Mar;89(3):298-302. Abstract

95. Mofidi R, Duff MD, Wigmore SJ, et al. Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis. Br J Surg. 2006 Jun;93(6):738-44. Abstract

96. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818-29. Abstract

97. Wu BU, Banks PA. Clinical management of patients with acute pancreatitis. Gastroenterology. 2013 Jun;144(6):1272-81.Full text  Abstract

98. Lankisch PG, Weber-Dany B, Hebel K, et al. The harmless acute pancreatitis score: a clinical algorithm for rapid initial stratification of nonsevere disease. Clin Gastroenterol Hepatol. 2009 Jun;7(6):702-5; quiz 607.Full text  Abstract

99. Hagjer S, Kumar N. Evaluation of the BISAP scoring system in prognostication of acute pancreatitis - a prospective observational study. Int J Surg. 2018 Jun;54(pt a):76-81.Full text  Abstract

100. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med 2018;56(12):2015-38. Abstract

101. Karslioglu French E, Donihi AC, Korytkowski MT. Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients. BMJ. 2019 May 29;365:l1114. Abstract

102. Joint British Diabetes Societies for Inpatient Care Group. The management of diabetic ketoacidosis in adults. Mar 2023 [internet publication].Full text

103. Melzer M, Toner R, Lacey S, et al. Biliary tract infection and bacteraemia: presentation, structural abnormalities, causative organisms and clinical outcomes. Postgrad Med J. 2007 Dec;83(986):773-6.Full text  Abstract

104. Nasr JY, Papachristou GI. Early fluid resuscitation in acute pancreatitis: a lot more than just fluids. Clin Gastroenterol Hepatol. 2011 Aug;9(8):633-4.Full text

105. Waller A, Long B, Koyfman A, et al. Acute pancreatitis: updates for emergency clinicians. J Emerg Med. 2018 Dec;55(6):769-79. Abstract

106. Crockett SD, Wani S, Gardner TB, et al. American Gastroenterological Association Institute guideline on initial management of acute pancreatitis. Gastroenterology. 2018 Mar;154(4):1096-101. Abstract

107. Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet. 2015 Jan 21;386(9988):85-96.Full text  Abstract

108. Liang XY, Wu XA, Tian Y, et al. Effects of early versus delayed feeding in patients with acute pancreatitis: a systematic review and meta-analysis. J Clin Gastroenterol. 2024 May-Jun 01;58(5):522-30. Abstract

109. Bollen TL, Singh VK, Maurer R, et al. A comparative evaluation of radiologic and clinical scoring systems in the early prediction of severity in acute pancreatitis. Am J Gastroenterol. 2012 Apr;107(4):612-9. Abstract

110. Boxhoorn L, van Dijk SM, van Grinsven J, et al. Immediate versus postponed intervention for infected necrotizing pancreatitis. N Engl J Med. 2021 Oct 7;385(15):1372-81.Full text  Abstract

111. Wu BU, Hwang JQ, Gardner TH, et al. Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol. 2011 Aug;9(8):710-7.e1.Full text  Abstract

112. de-Madaria E, Herrera-Marante I, González-Camacho V, et al. Fluid resuscitation with lactated Ringer's solution vs normal saline in acute pancreatitis: a triple-blind, randomized, controlled trial. United European Gastroenterol J. 2018 Feb;6(1):63-72.Full text  Abstract

113. Li XW, Wang CH, Dai JW, et al. Comparison of clinical outcomes between aggressive and non-aggressive intravenous hydration for acute pancreatitis: a systematic review and meta-analysis. Crit Care. 2023 Mar 22;27(1):122.Full text  Abstract

114. Wall I, Badalov N, Baradarian R, et al. Decreased mortality in acute pancreatitis related to early aggressive hydration. Pancreas. 2011 May;40(4):547-50. Abstract

115. Gardner TB, Vege SS, Pearson RK, et al. Fluid resuscitation in acute pancreatitis. Clin Gastroenterol Hepatol. 2008 Jul 10;6(10):1070-6.Full text  Abstract

116. Zampieri FG, Machado FR, Biondi RS, et al. Effect of intravenous fluid treatment with a balanced solution vs 0.9% saline solution on mortality in critically ill patients: the BaSICS randomized clinical trial. JAMA. 2021 Aug 10;326(9):1-12.Full text  Abstract

117. Finfer S, Micallef S, Hammond N, et al. Balanced multielectrolyte solution versus saline in critically ill adults. N Engl J Med. 2022 Mar 3;386(9):815-26. Abstract

118. Hammond NE, Zampieri FG, Di Tanna GL, et al. Balanced crystalloids versus saline in critically ill adults: a systematic review with meta-analysis. NEJM Evid. 2022 Jan 18;1(2).Full text

119. Zampieri FG, Cavalcanti AB, Di Tanna GL, et al. Balanced crystalloids versus saline for critically ill patients (BEST-Living): a systematic review and individual patient data meta-analysis. Lancet Respir Med. 2024 Mar;12(3):237-46. Abstract

120. Young P, Bailey M, Beasley R, et al. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial. JAMA. 2015 Oct 27;314(16):1701-10.Full text  Abstract

121. Semler MW, Self WH, Wanderer JP, et al. Balanced crystalloids versus saline in critically ill adults. N Engl J Med. 2018 Feb 27;378(9):829-39.Full text  Abstract

122. Antequera Martín AM, Barea Mendoza JA, Muriel A, et al. Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children. Cochrane Database Syst Rev. 2019 Jul 19;(7):CD012247.Full text  Abstract

123. de-Madaria E, Buxbaum JL, Maisonneuve P, et al. Aggressive or moderate fluid resuscitation in acute pancreatitis. N Engl J Med. 2022 Sep 15;387(11):989-1000.Full text  Abstract

124. Mao EQ, Tang YQ, Fei J, et al. Fluid therapy for severe acute pancreatitis in acute response stage. Chin Med J (Engl). 2009 Jan 20;122(2):169-73. Abstract

125. Mao EQ, Fei J, Peng YB, et al. Rapid hemodilution is associated with increased sepsis and mortality among patients with severe acute pancreatitis. Chin Med J (Engl). 2010 Jul;123(13):1639-44. Abstract

126. Buxbaum JL, Quezada M, Da B, et al. Early aggressive hydration hastens clinical improvement in mild acute Pancreatitis. Am J Gastroenterol. 2017 Mar 7;112(5):797-803. Abstract

127. Basurto Ona X, Rigau Comas D, Urrútia G. Opioids for acute pancreatitis pain. Cochrane Database Syst Rev. 2013 Jul 26;(7):CD009179.Full text  Abstract

128. Poropat G, Giljaca V, Hauser G, et al. Enteral nutrition formulations for acute pancreatitis. Cochrane Database Syst Rev. 2015 Mar 23;(3):CD010605.Full text  Abstract

129. Petrov MS, Loveday BP, Pylypchuk RD, et al. Systematic review and meta-analysis of enteral nutrition formulations in acute pancreatitis. Br J Surg. 2009 Nov;96(11):1243-52. Abstract

130. Al-Omran M, Albalawi ZH, Tashkandi MF, et al. Enteral versus parenteral nutrition for acute pancreatitis. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD002837.Full text  Abstract

131. Sun JK, Mu XW, Li WQ, et al. Effects of early enteral nutrition on immune function of severe acute pancreatitis patients. World J Gastroenterol. 2013 Feb 14;19(6):917-22.Full text  Abstract

132. Hsieh PH, Yang TC, Kang EY, et al. Impact of nutritional support routes on mortality in acute pancreatitis: a network meta-analysis of randomized controlled trials. J Intern Med. 2024 Jun;295(6):759-73. Abstract

133. Eatock FC, Chong P, Menezes N, et al. A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol. 2005 Feb;100(2):432-9. Abstract

134. Kumar A, Singh N, Prakash S, et al. Early enteral nutrition in severe acute pancreatitis: a prospective randomized controlled trial comparing nasojejunal and nasogastric routes. J Clin Gastroenterol. 2006 May-Jun;40(5):431-4. Abstract

135. Dutta AK, Goel A, Kirubakaran R, et al. Nasogastric versus nasojejunal tube feeding for severe acute pancreatitis. Cochrane Database Syst Rev. 2020 Mar 26;(3):CD010582.Full text  Abstract

136. Arvanitakis M, Ockenga J, Bezmarevic M, et al. ESPEN guideline on clinical nutrition in acute and chronic pancreatitis. Clin Nutr. 2020 Mar;39(3):612-31.Full text  Abstract

137. Besselink MG, van Santvoort HC, Boermeester MA, et al. Timing and impact of infections in acute pancreatitis. Br J Surg. 2009 Mar;96(3):267-73. Abstract

138. García-Barrasa A, Borobia FG, Pallares R, et al. A double-blind, placebo-controlled trial of ciprofloxacin prophylaxis in patients with acute necrotizing pancreatitis. J Gastrointest Surg. 2008 Dec 11;13(4):768-74. Abstract

139. Isenmann R, Rünzi M, Kron M, et al. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double-blind trial. Gastroenterology. 2004 Apr;126(4):997-1004. Abstract

140. Dellinger EP, Tellado JM, Soto NE, et al. Early antibiotic treatment for severe acute necrotizing pancreatitis: a randomized, double-blind, placebo-controlled study. Ann Surg. 2007 May;245(5):674-83. Abstract

141. Lim CL, Lee W, Liew YX, et al. Role of antibiotic prophylaxis in necrotizing pancreatitis: a meta-analysis. J Gastrointest Surg. 2015 Jan 22;19(3):480-91. Abstract

142. Villatoro E, Mulla M, Larvin M. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst Rev. 2010 May 12;(5):CD002941.Full text  Abstract

143. Gurusamy KS, Nagendran M, Davidson BR. Early versus delayed laparoscopic cholecystectomy for acute gallstone pancreatitis. Cochrane Database Syst Rev. 2013 Sep 2;(9):CD010326.Full text  Abstract

144. van Baal MC, Besselink MG, Bakker OJ, et al. Timing of cholecystectomy after mild biliary pancreatitis: a systematic review. Ann Surg. 2012 May;255(5):860-6. Abstract

145. Wilson CT, de Moya MA. Cholecystectomy for acute gallstone pancreatitis: early vs delayed approach. Scand J Surg. 2010;99(2):81-5. Abstract

146. Kimura Y, Arata S, Takada T, et al. Gallstone-induced acute pancreatitis. J Hepatobiliary Pancreat Sci. 2009 Dec 11;17(1):60-9. Abstract

147. da Costa DW, Bouwense SA, Schepers NJ, et al. Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial. Lancet. 2015 Sep 26;386(10000):1261-8. Abstract

148. Neoptolemos JP, Carr-Locke DL, London NJ, et al. Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet. 1988 Oct 29;2(8618):979-83. Abstract

149. Moretti A, Papi C, Aratari A, et al. Is early endoscopic retrograde cholangiopancreatography useful in the management of acute biliary pancreatitis? A meta-analysis of randomized controlled trials. Dig Liver Dis. 2008 May;40(5):379-85. Abstract

150. Tse F, Yuan Y. Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in acute gallstone pancreatitis. Cochrane Database Syst Rev. 2012 May 16;(5):CD009779.Full text  Abstract

151. Schepers NJ, Bakker OJ, Besselink MG, et al. Early biliary decompression versus conservative treatment in acute biliary pancreatitis (APEC trial): study protocol for a randomized controlled trial. Trials. 2016 Jan 5;17:5.Full text  Abstract

152. van Santvoort HC, Bakker OJ, Besselink MG, et al. Prediction of common bile duct stones in the earliest stages of acute biliary pancreatitis. Endoscopy. 2010 Oct 22;43(1):8-13. Abstract

153. De Lisi S, Leandro G, Buscarini E. Endoscopic ultrasonography versus endoscopic retrograde cholangiopancreatography in acute biliary pancreatitis: a systematic review. Eur J Gastroenterol Hepatol. 2011 May;23(5):367-74.Full text  Abstract

154. Bråthen G, Ben-Menachem E, Brodtkorb E, et al. Chapter 29: alcohol-related seizures. EFNS guidelines of alcohol-related seizures. In: Gilhus NE, Barnes MP, Brainin M, eds. European handbook of neurological management. 2nd ed, v1. Oxford, UK: Blackwell Publishing; 2011:429-36.

155. National Institute for Health and Care Excellence. Alcohol-use disorders: diagnosis and management of physical complications. April 2017 [internet publication].Full text

156. Rusu A, Munteanu AC, Arbănași EM, et al. Overview of side-effects of antibacterial fluoroquinolones: new drugs versus old drugs, a step forward in the safety profile? Pharmaceutics. 2023 Mar 1;15(3):804.Full text  Abstract

157. Rasslan R, Novo FDCF, Bitran A, et al. Management of infected pancreatic necrosis: state of the art. Rev Col Bras Cir. 2017 Sep-Oct;44(5):521-9.Full text  Abstract

158. Petrov MS, Kukosh MV, Emelyanov NV. A randomized controlled trial of enteral versus parenteral feeding in patients with predicted severe acute pancreatitis shows a significant reduction in mortality and in infected pancreatic complications with total enteral nutrition. Dig Surg. 2006 Dec 12;23(5-6):336-44; discussion 344-5.Full text  Abstract

159. Rodriguez JR, Razo AO, Targarona J, et al. Debridement and closed packing for sterile or infected necrotizing pancreatitis: insights into indications and outcomes in 167 patients. Ann Surg. 2008 Feb;247(2):294-9. Abstract

160. van Santvoort HC, Besselink MG, Bakker OJ, et al. A step-up approach or open necrosectomy for necrotizing pancreatitis. N Engl J Med. 2010 Apr 22;362(16):1491-502.Full text  Abstract

161. Adler DG, Chari ST, Dahl TJ, et al. Conservative management of infected necrosis complicating severe acute pancreatitis. Am J Gastroenterol. 2003 Jan;98(1):98-103. Abstract

162. Runzi M, Niebel W, Goebell H, et al. Severe acute pancreatitis: nonsurgical treatment of infected necroses. Pancreas. 2005 Apr;30(3):195-9. Abstract

163. Mouli VP, Sreenivas V, Garg PK. Efficacy of conservative treatment, without necrosectomy, for infected pancreatic necrosis: a systematic review and meta-analysis. Gastroenterology. 2012 Oct 12;144(2):333-340.e2.Full text  Abstract

164. van Brunschot S, van Grinsven J, van Santvoort HC, et al. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet. 2017 Nov 3;391(10115):51-58. Abstract

165. Horvath K, Freeny P, Escallon J, et al. Safety and efficacy of video-assisted retroperitoneal debridement for infected pancreatic collections: a multicenter, prospective, single-arm phase 2 study. Arch Surg. 2010 Sep;145(9):817-25.Full text  Abstract

166. Gurusamy KS, Belgaumkar AP, Haswell A, et al. Interventions for necrotising pancreatitis. Cochrane Database Syst Rev. 2016 Apr 16;(4):CD011383.Full text  Abstract

167. Raraty MG, Halloran CM, Dodd S, et al. Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach. Ann Surg. 2010 May;251(5):787-93. Abstract

168. Gomatos IP, Halloran CM, Ghaneh P, et al. Outcomes from minimal access retroperitoneal and open pancreatic necrosectomy in 394 patients With necrotizing pancreatitis. Ann Surg. 2016 May;263(5):992-1001. Abstract

169. Logue JA, Carter CR. Minimally invasive necrosectomy techniques in severe acute pancreatitis: role of percutaneous necrosectomy and video-assisted retroperitoneal debridement. Gastroenterol Res Pract. 2015 Oct 26;2015:693040.Full text  Abstract

170. van Santvoort HC, Bakker OJ, Bollen TL, et al. A conservative and minimally invasive approach to necrotizing pancreatitis improves outcome. Gastroenterology. 2011 Jul 8;141(4):1254-63.Full text  Abstract

171. Besselink MG, Verwer TJ, Schoenmaeckers EJ, et al. Timing of surgical intervention in necrotizing pancreatitis. Arch Surg. 2007 Dec;142(12):1194-201.Full text  Abstract

172. Mier J, León EL, Castillo A, et al. Early versus late necrosectomy in severe necrotizing pancreatitis. Am J Surg. 1997 Feb;173(2):71-5. Abstract

173. van Grinsven J, van Brunschot S, Bakker OJ, et al. Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study. HPB (Oxford). 2015 Dec 20;18(1):49-56.Full text  Abstract

174. Vitas GJ, Sarr MG. Selected management of pancreatic pseudocysts: operative versus expectant management. Surgery. 1992 Feb;111(2):123-30. Abstract

175. Gurusamy KS, Pallari E, Hawkins N, et al. Management strategies for pancreatic pseudocysts. Cochrane Database Syst Rev. 2016 Apr 14;(4):CD011392.Full text  Abstract

176. Ranson JH, Rifkind KM, Roses DF, et al. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet. 1974 Jul;139(1):69-81. Abstract

177. De Bernardinis M, Violi V, Roncoroni L, et al. Discriminant power and information content of Ranson's prognostic signs in acute pancreatitis: a meta-analytic study. Crit Care Med. 1999 Oct;27(10):2272-83. Abstract

178. Kusminsky RE. Complications of central venous catheterization. J Am Coll Surg. 2007 Apr;204(4):681-96.Full text  Abstract

179. McGee DC, Gould MK. Preventing complications of central venous catheterization. N Engl J Med. 2003 Mar 20;348(12):1123-33.Full text  Abstract

180. Smith RN, Nolan JP. Central venous catheters. BMJ. 2013 Nov 11;347:f6570.Full text  Abstract

181. Reich DL. Monitoring in anesthesia and perioperative care. Cambridge: Cambridge University Press; 2011.

182. Abbott Northwestern Hospital Internal Medicine Residency. Internal jugular central venous line. 2022 [internet publication].Full text

183. Bishop L, Dougherty L, Bodenham A, et al. Guidelines on the insertion and management of central venous access devices in adults. Int J Lab Hematol. 2007 Aug;29(4):261-78.Full text  Abstract

184. Practice guidelines for central venous access 2020: an updated report by the American Society of Anesthesiologists Task Force on Central Venous Access. Anesthesiology. 2020 Jan;132(1):8-43.Full text  Abstract

185. Fletcher SJ, Bodenham AR. Safe placement of central venous catheters: where should the tip of the catheter lie? Br J Anaesth. 2000 Aug;85(2):188-91.Full text

186. Gibson F, Bodenham A. Misplaced central venous catheters: applied anatomy and practical management. Br J Anaesth. 2013 Mar;110(3):333-46.Full text

187. Schuster M, Nave H, Piepenbrock S, et al. The carina as a landmark in central venous catheter placement. Br J Anaesth. 2000 Aug;85(2):192-4.Full text

188. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;1(1):CD007798.Full text  Abstract

189. Li S, Gao L, Gong H, et al. Recurrence rates and risk factors for recurrence after first episode of acute pancreatitis: a systematic review and meta-analysis. Eur J Intern Med. 2023 Oct;116:72-81. Abstract

190. Sankaran SJ, Xiao AY, Wu LM, et al. Frequency of progression from acute to chronic pancreatitis and risk factors: a meta-analysis. Gastroenterology. 2015 Nov;149(6):1490-500.Full text  Abstract

191. Bouça-Machado T, Bouwense SAW, Brand M, et al. Position statement on the definition, incidence, diagnosis and outcome of acute on chronic pancreatitis. Pancreatology. 2023 Mar;23(2):143-50.Full text  Abstract

192. Herrera ME, Seller G, de la Rubia C, et al. Hemofiltration in acute pancreatitis [in Spanish]. Med Intensiva. 2003;27:137-43.

193. Sainio V, Kemppainen E, Puolakkainen P, et al. Early antibiotic treatment in acute necrotising pancreatitis. Lancet. 1995 Sep 9;346(8976):663-7. Abstract

194. Hernandez-Aranda JC, Gallo-Chico B, Ramirez-Barba EJ. Nutritional support in severe acute pancreatitis. Controlled clinical trial [in Spanish]. Nutr Hosp. 1996 May-Jun;11(3):160-6. Abstract

195. Kotani J, Usami M, Nomura H, et al. Enteral nutrition prevents bacterial translocation but does not improve survival during acute pancreatitis. Arch Surg. 1999 Mar;134(3):287-92. Abstract

196. Ammori BJ. Role of the gut in the course of severe acute pancreatitis. Pancreas. 2003 Mar;26(2):122-9. Abstract

197. Hart PA, Bradley D, Conwell DL, et al. Diabetes following acute pancreatitis. Lancet Gastroenterol Hepatol. 2021 Aug;6(8):668-75.Full text  Abstract

198. Whitcomb DC, Buchner AM, Forsmark CE. AGA clinical practice update on the epidemiology, evaluation, and management of exocrine pancreatic insufficiency: expert review. Gastroenterology. 2023 Nov;165(5):1292-301.Full text  Abstract

199. Zahariev OJ, Bunduc S, Kovács A, et al. Risk factors for diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis. Front Med (Lausanne). 2024 Jan 9:10:1257222.Full text  Abstract

200. Borbély RZ, Szalai EÁ, Philip BM, et al. The risk of developing splanchnic vein thrombosis in acute pancreatitis increases 3 days after symptom onset: a systematic review and meta-analysis. United European Gastroenterol J. 2024 Jul;12(6):678-90.Full text  Abstract

201. van Brunschot S, Schut AJ, Bouwense SA, et al. Abdominal compartment syndrome in acute pancreatitis: a systematic review. Pancreas. 2014 Jul;43(5):665-74.Full text  Abstract

202. Preiss D, Tikkanen MJ, Welsh P, et al. Lipid-modifying therapies and risk of pancreatitis: a meta-analysis. JAMA. 2012 Aug 22;308(8):804-11.Full text  Abstract

203. Andriulli A, Leandro G, Niro G, et al. Pharmacologic treatment can prevent pancreatic injury after ERCP: a meta-analysis. Gastrointest Endosc. 2000 Jan;51(1):1-7. Abstract

204. Venneman NG, van Erpecum KJ. Gallstone disease: primary and secondary prevention. Best Pract Res Clin Gastroenterol. 2006;20(6):1063-73. Abstract

205. Tse F, Yuan Y, Bukhari M, et al. Pancreatic duct guidewire placement for biliary cannulation for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Cochrane Database Syst Rev. 2016 May 16;(5):CD010571.Full text  Abstract

Comorbidities Manager reference articles

206. National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. Clinical guideline CG174. May 2017 [internet publication]Full text

207. Verbrugge FH, Grieten L, Mullens W. Management of the cardiorenal syndrome in decompensated heart failure. Cardiorenal Med. 2014 Dec;4(3-4):176-88Full text  Abstract

208. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr;21(2):69-72 Abstract

209. National Institute for Health and Care Excellence. Hypertension in adults. Nov 2023 [internet publication].Full text

210. Griffin M, Rao VS, Ivey-Miranda J, et al. Empagliflozin in heart failure: diuretic and cardiorenal effects. Circulation. 2020 Sep 15;142(11):1028-39.Full text  Abstract

211. Royal College of Physicians. National early warning score (NEWS2). Standardising the assessment of acute-illness severity in the NHS. December 2017 [internet publication]Full text

212. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2025 [internet publication]Full text

213. British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma: a national clinical guideline. Nov 2024 [internet publication]Full text

214. O'Driscoll BR, Howard LS, Earis J, et al. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax. 2017 Jun;72(suppl 1):ii1-90Full text  Abstract

215. Chu DK, Kim LH, Young PJ, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): systematic review and meta-analysis. Lancet. 2018 Apr 26;391(10131):1693-705 Abstract

216. Siemieniuk RAC, Chu DK, Kim LH, et al. Oxygen therapy for acutely ill medical patients: a clinical practice guideline. BMJ. 2018 Oct 24;363:k4169. Abstract

217. Davison SN. Clinical pharmacology considerations in pain management in patients with advanced kidney failure. Clin J Am Soc Nephrol. 2019 Jun 7;14(6):917-31Full text  Abstract

218. UK Kidney Association. Kidney Patient Safety Committee: safe prescribing of opiates in kidney disease. Nov 2020 [internet publication].Full text

219. National Institute for Health and Care Excellence. Acute kidney injury: prevention, detection and management. Oct 2024 [internet publication].Full text

220. McDonagh TA, Metra M, Adamo M, et al; ESC Scientific Document Group. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-726Full text  Abstract

221. Scottish Intercollegiate Guidelines Network. Risk reduction and management of delirium. Mar 2019 [internet publication].Full text

222. Nickel C, Arendts G, Lucke J, et al; British Geriatrics Society. Silver book II: geriatric syndromes. February 2021 [internet publication].Full text

223. National Institute for Health and Care Excellence. Fractures (non-complex): assessment and management. February 2016 [internet publication]Full text

224. National Institue for Health and Care Excellence. Palliative care for adults: strong opioids for pain relief. Aug 2016 [internet publication].Full text

225. Joint British Diabetes Societies for inpatient care. Diabetes at the Front Door. A guideline for dealing with glucose related emergencies at the time of acute hospital admission from the Joint British Diabetes Society (JBDS) for inpatient care. May 2023 [Internet publication].Full text

226. Umpierrez GE, Davis GM, ElSayed NA, et al. Hyperglycaemic crises in adults with diabetes: a consensus report. Diabetologia. 2024 Aug;67(8):1455-79.Full text  Abstract

227. Chowdhury TA, Cheston H, Claydon A. Managing adults with diabetes in hospital during an acute illness. BMJ. 2017 Jun 22;357:j2551 Abstract

228. Joint British Diabetes Societies for Inpatient Care. Self-management of diabetes in hospital. Feb 2023 [internet publication].Full text

229. Joint British Diabetes Societies for inpatient care and Diabetes Technology Network. Using technology to support diabetes care in hospital. Mar 2024 [internet publication].Full text

230. Joint British Diabetes Societies for Inpatient Care. Glycaemic management during enteral feeding for people with diabetes in hospital. Apr 2024 [internet publication].Full text

231. Joint British Diabetes Societies for Inpatient Care. The use of variable rate intravenous insulin infusion (VRIII) in medical inpatients. Oct 2014 [internet publication].Full text

232. Joint British Diabetes Societies for inpatient care. A good inpatient diabetes service. Jul 2019 [internet publication].Full text

233. Centre for Perioperative Care. Guideline for perioperative care for people with diabetes mellitus undergoing elective and emergency surgery. Oct 2023 [internet publication].Full text

234. Pasquel FJ, Lansang MC, Dhatariya K, et al. Management of diabetes and hyperglycaemia in the hospital. Lancet Diabetes Endocrinol. 2021 Mar;9(3):174-88.Full text  Abstract

235. Medicines and Healthcare Products Regulatory Agency. SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness. Mar 2020 [internet publication].Full text

236. Peters AL, Buschur EO, Buse JB, et al. Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015 Jun 15;38(9):1687-93 Abstract

237. Umapathysivam MM, Gunton J, Stranks SN, et al. Euglycemic ketoacidosis in two patients without diabetes after introduction of sodium-glucose cotransporter 2 inhibitor for heart failure with reduced ejection fraction. Diabetes Care. 2024 Jan 1;47(1):140-3.Full text  Abstract

238. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024 Apr;105(4s):S117-S314.Full text  Abstract

239. Medicines and Healthcare products Regulatory Agency. MHRA Safety update: GLP-1 and dual GIP/GLP-1 receptor agonists: potential risk of pulmonary aspiration during general anaesthesia or deep sedation. Jan 2025 [internet publication].Full text

240. American Diabetes Association Professional Practice Committee. 16. Diabetes care in the hospital: standards of care in diabetes-2025. Diabetes Care. 2025 Jan 1;48(1 Suppl 1):S321-34.Full text  Abstract

241. Hogervorst VM, Buurman BM, De Jonghe A, et al. Emergency department management of older people living with frailty: a guide for emergency practitioners. Emerg Med J. 2021 Sep;38(9):724-9 Abstract

242. British Geriatric Society, Centre for Perioperative Care. Guideline for the care of people living with frailty undergoing elective and emergency surgery that encompasses the whole perioperative pathway. Sep 2021 [internet publication].Full text

243. NHS England. Toolkit for general practice in supporting older people living with frailty. March 2017 [internet publication]Full text

244. British Geriatrics Society (BGS), Getting It Right First Time (GIRFT). Six steps to better care for older people in acute hospitals. Jul 2023 [internet publication].Full text

245. Rockwood K; British Geriatrics Society. Silver book II: frailty. February 2021 [internet publication]Full text

246. Falk Erhag H, Guðnadóttir G, Alfredsson J, et al. The association between the clinical frailty scale and adverse health outcomes in older adults in acute clinical settings: a systematic review of the literature. Clin Interv Aging. 2023 Feb;18:249-61.Full text  Abstract

247. Conroy SP, Bardsley M, Smith P, et al. Comprehensive geriatric assessment for frail older people in acute hospitals: the HoW-CGA mixed-methods study. Health Services and Delivery Research. 2019 April:7(15)Full text

248. Quinn TJ, Mooijaart SP, Gallacher K, et al. Acute care assessment of older adults living with frailty. BMJ. 2019 Jan 31;364:l13 Abstract

249. Fritz Z, Slowther AM, Perkins GD. Resuscitation policy should focus on the patient, not the decision. BMJ. 2017 Feb 28;356:j813Full text  Abstract

250. British Medical Association, the Resuscitation Council (UK) and the Royal College of Nursing. Decisions relating to cardiopulmonary resuscitation. 2016 [internet publication].Full text

251. The National Institute for Health and Care Excellence. Decision making and mental capacity. October 2018 [internet publication]Full text

252. Office of the Public Guardian. Mental Capacity Act: making decisions. Jun 2023 [internet publication]Full text

253. Social Care Institute for Excellence. Independent mental capacity advocate (IMCA). January 2010 [internet publication]Full text

254. Grau AJ, Urbanek C, Palm F. Common infections and the risk of stroke. Nat Rev Neurol. 2010 Nov 9;6(12):681-94 Abstract

255. Elkind MSV, Boehme AK, Smith CJ, et al. Infection as a stroke risk factor and determinant of outcome after stroke. Stroke. 2020 Oct;51(10):3156-68.Full text  Abstract

256. Eigenbrodt ML, Rose KM, Couper DJ, et al. Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke. 2000 Oct;31(10):2307-13 Abstract

257. Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016 May 4;47(6):e98-e169Full text  Abstract

258. Pendlebury ST, Klaus SP, Mather M, et al. Routine cognitive screening in older patients admitted to acute medicine: abbreviated mental test score (AMTS) and subjective memory complaint versus Montreal Cognitive Assessment and IQCODE. Age Ageing. 2015 Oct 13;44(6):1000-5Full text  Abstract

259. Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing. 1972 Nov;1(4):233-8 Abstract

260. Emery A, Wells J, Klaus SP, et al. Underestimation of cognitive impairment in older inpatients by the Abbreviated Mental Test Score versus the Montreal Cognitive Assessment: cross-sectional observational study. Dement Geriatr Cogn Dis Extra. 2020 Sep-Dec;10(3):205-15.Full text  Abstract

261. Bellelli G, Morandi A, Davis DH, et al. Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing. 2014 Mar 2;43(4):496-502.Full text  Abstract

262. National Institute for Health and Care Excellence. Delirium: prevention, diagnosis and management in hospital and long-term care. Jan 2023 [internet publication].Full text

263. Tieges Z, Maclullich AMJ, Anand A, et al. Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis. Age Ageing. 2021 May 5;50(3):733-43.Full text  Abstract

264. Zhang XM, Jiao J, Xie XH, et al. The association between frailty and delirium among hospitalized patients: an updated meta-analysis. J Am Med Dir Assoc. 2021 Mar;22(3):527-34. Abstract

265. National Institute for Health and Care Excellence. Dementia: assessment, management and support for people living with dementia and their carers. Jun 2018 [internet publication].Full text

266. Bishara D. Managing drugs with anticholinergic activity. Drug Ther Bull. 2023 Sep;61(9):135-9.Full text  Abstract

267. Lisibach A, Gallucci G, Benelli V, et al. Evaluation of the association of anticholinergic burden and delirium in older hospitalised patients: a cohort study comparing 19 anticholinergic burden scales. Br J Clin Pharmacol. 2022 Nov;88(11):4915-27.Full text  Abstract

268. Smith H, Fligelstone H. Reducing patient and planetary harms from high anticholinergic burden medication. BMJ. 2024 Jan 15;384:e075708.Full text  Abstract

269. Gracie TJ, Caufield-Noll C, Wang NY, et al. The association of preoperative frailty and postoperative delirium: a meta-analysis. Anesth Analg. 2021 Aug 1;133(2):314-23.Full text  Abstract

270. Liu CY, Gong N, Liu W. The association between preoperative frailty and postoperative delirium: a systematic review and meta-analysis. J Perianesth Nurs. 2022 Feb;37(1):53-62.e1. Abstract

271. White S, Griffiths R, Baxter M, et al. Guidelines for the peri-operative care of people with dementia: guidelines from the Association of Anaesthetists. Anaesthesia. 2019 Jan 11;74(3):357-72Full text  Abstract

272. Burton JK, Craig L, Yong SQ, et al. Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. 2021 Nov 26;(11):CD013307.Full text  Abstract

273. UK Health Security Agency. Urinary tract infection: diagnostic tools for primary care. Jul 2025 [internet publication]Full text

274. Medicines and Healthcare products Regulatory Agency. Haloperidol (haldol): reminder of risks when used in elderly patients for the acute treatment of delirium. Dec 2021 [internet publication]Full text

275. Mühlbauer V, Möhler R, Dichter MN, et al. Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev. 2021 Dec 17;12(12):CD013304.Full text  Abstract

276. Yunusa I, Alsumali A, Garba AE, et al. Assessment of reported comparative effectiveness and safety of atypical antipsychotics in the treatment of behavioral and psychological symptoms of dementia: a network meta-analysis. JAMA Netw Open. 2019 Mar 1;2(3):e190828.Full text  Abstract

277. Van Leeuwen E, Petrovic M, van Driel ML, et al. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2018 Mar 30;3:CD007726.Full text  Abstract

278. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13 Abstract

279. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011 May;106(5):906-14. Abstract

280. American Diabetes Association Professional Practice Committee. 16. Diabetes care in the hospital: standards of care in diabetes - 2025. Diabetes Care. 2025 Jan 1;48(1 suppl 1):S321-34.Full text  Abstract

281. Joint British Diabetes Societies for Inpatient Care. A good inpatient diabetes service. Jul 2019 [internet publication].Full text

282. Joint British Diabetes Societies for Inpatient Care. Inpatient care of the frail older adult with diabetes. Feb 2023 [internet publication].Full text

283. National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. Aug 2022 [internet publication].Full text

284. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67Full text  Abstract

285. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 Mar 26;360(13):1283-97.Full text  Abstract

286. Yamada T, Shojima N, Noma H, et al. Glycemic control, mortality, and hypoglycemia in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials. Intensive Care Med. 2017 Jan;43(1):1-15. Abstract

287. Yatabe T, Inoue S, Sakaguchi M, et al. The optimal target for acute glycemic control in critically ill patients: a network meta-analysis. Intensive Care Med. 2017 Jan;43(1):16-28. Abstract

288. Pasquel FJ, Lansang MC, Dhatariya K, et al. Management of diabetes and hyperglycaemia in the hospital. Lancet Diabetes Endocrinol. 2021 Mar;9(3):174-88Full text  Abstract

289. Joint British Diabetes Societies for Inpatient Care. The management of diabetic ketoacidosis in adults. Mar 2023 [internet publication].Full text

290. Joint British Diabetes Societies for Inpatient Care. The management of the hyperosmolar hyperglycaemic state (HHS) in adults. Feb 2022 [internet publication].Full text

291. Rehman A, Setter SM, Vue MH. Drug-induced glucose alterations part 2: drug-Induced hyperglycemia. Diabetes Spect. 2011 Nov;24(4):234-8Full text

292. Joint British Diabetes Societies for Inpatient Care. The hospital management of hypoglycaemia in adults with diabetes mellitus. Jan 2023 [internet publication].Full text

293. Joint British Diabetes Societies for Inpatient Care; Diabetes Technology Network. Using technology to support diabetes care in hospital. Mar 2024 [internet publication].Full text

294. TREND Diabetes. End of life guidance for diabetes care. Jun 2024 [internet publication]Full text

295. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication]Full text

296. Senneville É, Albalawi Z, van Asten SA, et al. IWGDF/IDSA guidelines on the diagnosis and treatment of diabetes-related foot infections (IWGDF/IDSA 2023). Diabetes Metab Res Rev. 2024 Mar;40(3):e3687.Full text  Abstract

297. Rayman G, Vas PR, Baker N, et al. The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration. Diabetes Care. 2011 May 18;34(7):1517-8Full text  Abstract

298. Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004 Jun;125(6):2309-21Full text  Abstract

299. Au DH, Curtis JR, Every NR, et al. Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest. 2002 Mar;121(3):846-51Full text  Abstract

300. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. 2025 [internet publication].Full text

301. Walters JA, Tan DJ, White CJ, et al. Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018 Mar 19;3:CD006897Full text  Abstract

302. National Institute for Health and Care Excellence. Chronic obstructive pulmonary disease in over 16s: diagnosis and management. July 2019 [internet publication]Full text

303. National Institute for Health and Care Excellence. Depression in adults: treatment and management. Jun 2022 [internet publication]Full text

304. Horowitz M, Taylor DM. The Maudsley deprescribing guidelines: antidepressants, benzodiazepines, gabapentinoids and Z-drugs. Chichester: Wiley-Blackwell; 2024.

305. Taylor DM, Barnes TRE, Young AH. The Maudsley prescribing guidelines in psychiatry. 14th edition. Chichester: Wiley-Blackwell; 2021

306. Cleare A, Pariante CM, Young AH, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2015 May 12;29(5):459-525Full text  Abstract

307. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20. Abstract

308. Buckley NA, Dawson AH, Isbister GK. Serotonin syndrome. BMJ. 2014 Feb 19;348:g1626 Abstract

309. Nochaiwong S, Ruengorn C, Awiphan R, et al. Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis. Ann Med. 2022 Dec;54(1):80-97Full text  Abstract

310. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther. 2008 Jan 1;27(1):31-40Full text  Abstract

311. Flowers L. Nicotine replacement therapy. Am J Psychiatry Resid. 2016 Jun;11(6)4-7Full text

312. Desai HD, Seabolt J, Jann MW. Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective. CNS Drugs. 2001;15(6):469-94 Abstract

313. Oliveira P, Ribeiro J, Donato H, Madeira N. Smoking and antidepressants pharmacokinetics: a systematic review. Ann Gen Psychiatry. 2017;16:17Full text  Abstract

314. Roose SP, Rutherford BR. Selective serotonin reuptake inhibitors and operative bleeding risk: a review of the literature. J Clin Psychopharmacol. 2016 Dec;36(6):704-9 Abstract

315. National Institute for Health and Care Excellence. Liaison psychiatry. In: Emergency acute medical care in over 16s: service delivery and organisation. March 2018 [internet publication]Full text

316. National Confidential Enquiry into Patient Outcome and Death (NCEPOD). Treat as one. Bridging the gap between mental and physical healthcare in general hospitals. 2017 [internet publication]Full text

317. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 Jul 24;160(14):2101-7 Abstract

318. Clarke DM, Currie KC. Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence. Med J Aust. 2009 Apr 6;190(S7):S54-60 Abstract

319. National Institute for Health and Care Excellence. Depression in adults with a chronic physical health problem: recognition and management. October 2009 [internet publication]Full text

320. Prina AM, Cosco TD, Dening T, et al. The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review. J Psychosom Res. 2015 Jan;78(1):25-33Full text  Abstract

321. Archer G, Kuh D, Hotopf M, et al. Association between lifetime affective symptoms and premature mortality. JAMA Psychiatry. 2020 Aug 1;77(8):806-13Full text  Abstract

322. Machado MO, Veronese N, Sanches M, et al. The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses. BMC Med. 2018 Jul 20;16(1):112Full text  Abstract

323. National Institute for Health and Care Excellence. Tobacco: preventing uptake, promoting quitting and treating dependence. Feb 2025 [internet publication].Full text

324. Theodoulou A, Chepkin SC, Ye W, et al. Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2023 Jun 19;6(6):CD013308Full text  Abstract

325. Rigotti NA, Kruse GR, Livingstone-Banks J, et al. Treatment of tobacco smoking: a review. JAMA. 2022 Feb 8;327(6):566-77.Full text  Abstract

326. Agrawal S, Evison M, Ananth S, et al. Medical management of inpatients with tobacco dependency. Thorax. 2024 Mar 26;79(suppl 1):3-11.Full text  Abstract

327. Lindson N, Theodoulou A, Ordóñez-Mena JM, et al. Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta-analyses. Cochrane Database Syst Rev. 2023 Sep 12;9(9):CD015226.Full text  Abstract

328. Thomas KH, Dalili MN, López-López JA, et al. Comparative clinical effectiveness and safety of tobacco cessation pharmacotherapies and electronic cigarettes: a systematic review and network meta-analysis of randomized controlled trials. Addiction. 2022 Apr;117(4):861-76.Full text  Abstract

329. Livingstone-Banks J, Fanshawe TR, Thomas KH, et al. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2023 June 28;6(6):CD006103Full text

330. Streck JM, Rigotti NA, Livingstone-Banks J, et al. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev. 2024 May 21;5(5):CD001837.Full text  Abstract

331. Livingstone-Banks J, Vidyasagaran AL, Croucher R, et al. Interventions for smokeless tobacco use cessation. Cochrane Database Syst Rev. 2025 Apr 15;4(4):CD015314.Full text  Abstract

332. Kerry C, Mitchell S, Sharma S, et al. Diurnal temporal patterns of hypoglycaemia in hospitalized people with diabetes may reveal potentially correctable factors. Diabet Med. 2013 Dec;30(12):1403-6 Abstract

333. Rajendran R, Kerry C, Rayman G, et al. Temporal patterns of hypoglycaemia and burden of sulfonylurea-related hypoglycaemia in UK hospitals: a retrospective multicentre audit of hospitalised patients with diabetes. BMJ Open. 2014 Jul 9;4(7):e005165Full text  Abstract

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